STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ALOX5Arachidonate 5-lipoxygenase. (642 aa)    
Predicted Functional Partners:
LTC4S
Leukotriene C4 synthase.
   
 0.974
LTA4H
Leukotriene A(4) hydrolase; Belongs to the peptidase M1 family.
    
 0.964
PLA2G4A
Phospholipase A2.
    
 0.950
ALOX5AP
Arachidonate 5-lipoxygenase activating protein.
   
 0.949
PTGS2
Prostaglandin-endoperoxide synthase 2.
   
 
 0.937
PTGS1
Prostaglandin G/H synthase 1; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (By similarity).
   
 
 0.937
GPX6
Glutathione peroxidase; Belongs to the glutathione peroxidase family.
   
 0.923
GPX2
Glutathione peroxidase; Belongs to the glutathione peroxidase family.
   
 0.923
GPX5
Epididymal secretory glutathione peroxidase; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.
   
 0.923
GPX8
Glutathione peroxidase; Belongs to the glutathione peroxidase family.
   
 0.923
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.