STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LGI4Leucine rich repeat LGI family member 4. (534 aa)    
Predicted Functional Partners:
ADAM22
ADAM metallopeptidase domain 22.
   
  
 0.831
ADAM23
ADAM metallopeptidase domain 23.
      
 0.658
ADGRG6
Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family.
      
 0.623
ADAM11
ADAM metallopeptidase domain 11.
      
 0.606
MPZ
Myelin protein zero.
   
  
 0.590
METRNL
Meteorin like, glial cell differentiation regulator.
   
  
 0.557
PTPRN
Protein tyrosine phosphatase receptor type N.
      
 0.533
GPSM1
G protein signaling modulator 1.
      
 0.527
PPP2R5B
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
      
 0.526
SEMA4F
Ssemaphorin 4F; Belongs to the semaphorin family.
      
 0.526
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.