STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
FEZF2FEZ family zinc finger 2. (470 aa)    
Predicted Functional Partners:
SATB2
DNA-binding protein SATB.
    
 
 0.892
TBR1
T-box brain transcription factor 1.
   
 
 0.859
NEUROD6
Neurogenic differentiation factor.
   
 
 0.669
TLE4
TLE family member 4, transcriptional corepressor.
    
 
 0.656
CUX2
Homeobox protein cut-like.
    
 
 0.644
SOX5
SRY-box 5.
    
 
 0.644
EMX2
Empty spiracles homeobox 2.
   
 
 0.622
NEUROG1
Neurogenin 1.
   
 
 0.612
ASCL1
Achaete-scute family bHLH transcription factor 1.
   
 
 0.592
CUX1
Homeobox protein cut-like 1; Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer (By similarity).
    
 
 0.581
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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