LMO2 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

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gene neighborhood

gene co-occurrence

gene fusions

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[Homology]

Score

LMO2

LIM domain only 2. (154 aa)

Predicted Functional Partners:

TAL1

0.994

LDB1

0.985

GATA1

0.964

LDB2

0.912

GATA2

0.844

POLR2G

0.807

RUNX1

0.802

LYL1

0.775

POLR2C

0.774

RECQL5

0.773

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GATA1	GATA2	ENSCAFP00000022898	ENSCAFP00000006152	GATA binding protein 1.	GATA binding protein 2.	0.439
GATA1	LDB1	ENSCAFP00000022898	ENSCAFP00000014734	GATA binding protein 1.	LIM domain binding 1.	0.671
GATA1	LDB2	ENSCAFP00000022898	ENSCAFP00000046020	GATA binding protein 1.	LIM domain binding 2.	0.572
GATA1	LMO2	ENSCAFP00000022898	ENSCAFP00000010588	GATA binding protein 1.	LIM domain only 2.	0.964
GATA1	RUNX1	ENSCAFP00000022898	ENSCAFP00000014111	GATA binding protein 1.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.762
GATA1	TAL1	ENSCAFP00000022898	ENSCAFP00000005977	GATA binding protein 1.	TAL bHLH transcription factor 1, erythroid differentiation factor.	0.977
GATA2	GATA1	ENSCAFP00000006152	ENSCAFP00000022898	GATA binding protein 2.	GATA binding protein 1.	0.439
GATA2	LDB1	ENSCAFP00000006152	ENSCAFP00000014734	GATA binding protein 2.	LIM domain binding 1.	0.567
GATA2	LDB2	ENSCAFP00000006152	ENSCAFP00000046020	GATA binding protein 2.	LIM domain binding 2.	0.400
GATA2	LMO2	ENSCAFP00000006152	ENSCAFP00000010588	GATA binding protein 2.	LIM domain only 2.	0.844
GATA2	LYL1	ENSCAFP00000006152	ENSCAFP00000059898	GATA binding protein 2.	Uncharacterized protein.	0.520
GATA2	RUNX1	ENSCAFP00000006152	ENSCAFP00000014111	GATA binding protein 2.	Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.	0.839
GATA2	TAL1	ENSCAFP00000006152	ENSCAFP00000005977	GATA binding protein 2.	TAL bHLH transcription factor 1, erythroid differentiation factor.	0.926
LDB1	GATA1	ENSCAFP00000014734	ENSCAFP00000022898	LIM domain binding 1.	GATA binding protein 1.	0.671
LDB1	GATA2	ENSCAFP00000014734	ENSCAFP00000006152	LIM domain binding 1.	GATA binding protein 2.	0.567
LDB1	LDB2	ENSCAFP00000014734	ENSCAFP00000046020	LIM domain binding 1.	LIM domain binding 2.	0.679
LDB1	LMO2	ENSCAFP00000014734	ENSCAFP00000010588	LIM domain binding 1.	LIM domain only 2.	0.985
LDB1	LYL1	ENSCAFP00000014734	ENSCAFP00000059898	LIM domain binding 1.	Uncharacterized protein.	0.501
LDB1	TAL1	ENSCAFP00000014734	ENSCAFP00000005977	LIM domain binding 1.	TAL bHLH transcription factor 1, erythroid differentiation factor.	0.927
LDB2	GATA1	ENSCAFP00000046020	ENSCAFP00000022898	LIM domain binding 2.	GATA binding protein 1.	0.572