STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TOXThymocyte selection associated high mobility group box. (526 aa)    
Predicted Functional Partners:
TOX3
TOX high mobility group box family member 3.
   
    0.931
TOX4
TOX high mobility group box family member 4.
   
    0.606
TOX2
TOX high mobility group box family member 2.
   
   0.572
PKNOX1
PBX/knotted 1 homeobox 1.
    
 
 0.544
PENK
Proenkephalin.
  
   
 0.502
PYCR1
Pyrroline-5-carboxylate reductase; Belongs to the pyrroline-5-carboxylate reductase family.
      
 0.486
TM9SF1
Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.
   
 
 0.482
CCRL2
C-C motif chemokine receptor like 2; Belongs to the G-protein coupled receptor 1 family.
   
  
 0.480
PPP1CB
Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...]
   
 
 0.478
SUPT16H
SPT16 homolog, facilitates chromatin remodeling subunit.
   
 
 0.464
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.