STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IFIT5Interferon induced protein with tetratricopeptide repeats 5. (483 aa)    
Predicted Functional Partners:
EIF2AK2
Eukaryotic translation initiation factor 2-alpha kinase 2.
   
 0.724
OASL
2'-5' oligoadenylate synthetase-like 1.
   
 
 0.688
ISG15
ISG15 ubiquitin like modifier.
   
 
 0.666
EIF3E
Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...]
    
  0.610
IFI6
Interferon alpha inducible protein 6.
   
 
 0.607
EIF2AK4
Eukaryotic translation initiation factor 2 alpha kinase 4.
   
 
 0.603
EIF2AK1
Eukaryotic translation initiation factor 2 alpha kinase 1.
   
 
 0.601
EIF2AK3
Eukaryotic translation initiation factor 2 alpha kinase 3.
    
  0.596
IFI44
Interferon induced protein 44.
   
  
 0.587
RSAD2
Radical S-adenosyl methionine domain containing 2.
   
 
 0.564
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.