node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATAD2 | GGH | ENSCAFP00000001411 | ENSCAFP00000010704 | ATPase family AAA domain containing 2. | Folate gamma-glutamyl hydrolase. | 0.556 |
ATIC | DHFR | ENSCAFP00000021114 | ENSCAFP00000036312 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | DHFR domain-containing protein. | 0.942 |
ATIC | FPGS | ENSCAFP00000021114 | ENSCAFP00000029808 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.554 |
ATIC | GGH | ENSCAFP00000021114 | ENSCAFP00000010704 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | Folate gamma-glutamyl hydrolase. | 0.527 |
ATIC | LOC609048 | ENSCAFP00000021114 | ENSCAFP00000038964 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. | 0.478 |
ATIC | RFC1 | ENSCAFP00000021114 | ENSCAFP00000063479 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | Replication factor C subunit 1. | 0.527 |
ATIC | TYMS | ENSCAFP00000021114 | ENSCAFP00000027096 | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | Thymidylate synthetase. | 0.653 |
DHFR | ATIC | ENSCAFP00000036312 | ENSCAFP00000021114 | DHFR domain-containing protein. | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | 0.942 |
DHFR | FPGS | ENSCAFP00000036312 | ENSCAFP00000029808 | DHFR domain-containing protein. | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.987 |
DHFR | GGH | ENSCAFP00000036312 | ENSCAFP00000010704 | DHFR domain-containing protein. | Folate gamma-glutamyl hydrolase. | 0.599 |
DHFR | TYMS | ENSCAFP00000036312 | ENSCAFP00000027096 | DHFR domain-containing protein. | Thymidylate synthetase. | 0.996 |
FPGS | ATIC | ENSCAFP00000029808 | ENSCAFP00000021114 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | 0.554 |
FPGS | DHFR | ENSCAFP00000029808 | ENSCAFP00000036312 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | DHFR domain-containing protein. | 0.987 |
FPGS | GGH | ENSCAFP00000029808 | ENSCAFP00000010704 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Folate gamma-glutamyl hydrolase. | 0.837 |
FPGS | LOC609048 | ENSCAFP00000029808 | ENSCAFP00000038964 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. | 0.878 |
FPGS | RFC1 | ENSCAFP00000029808 | ENSCAFP00000063479 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Replication factor C subunit 1. | 0.523 |
FPGS | TYMS | ENSCAFP00000029808 | ENSCAFP00000027096 | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | Thymidylate synthetase. | 0.973 |
GGH | ATAD2 | ENSCAFP00000010704 | ENSCAFP00000001411 | Folate gamma-glutamyl hydrolase. | ATPase family AAA domain containing 2. | 0.556 |
GGH | ATIC | ENSCAFP00000010704 | ENSCAFP00000021114 | Folate gamma-glutamyl hydrolase. | 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. | 0.527 |
GGH | DHFR | ENSCAFP00000010704 | ENSCAFP00000036312 | Folate gamma-glutamyl hydrolase. | DHFR domain-containing protein. | 0.599 |