STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
E2R960_CANLFUncharacterized protein. (78 aa)    
Predicted Functional Partners:
LOC484343
Uncharacterized protein.
     
 0.927
CD44
CD44 antigen.
      
 0.797
CD19
CD19 molecule.
      
 0.745
ALDH3A2
Multidrug and toxin extrusion protein; Belongs to the aldehyde dehydrogenase family.
      
 0.647
EPCAM
Epithelial cell adhesion molecule.
   
  
 0.629
CD22
CD22 molecule.
     
 0.627
ENSCAFP00000062374
IF rod domain-containing protein; Belongs to the intermediate filament family.
   
  
 0.608
LYN
Tyrosine-protein kinase.
    
 
 0.604
ALDH3A1
Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity). Preferentially oxidizes aromatic aldehyde substrates (By similarity). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).
      
 0.592
PROM1
Prominin 1.
      
 0.590
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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