UBA2 protein (Canis lupus familiaris) - STRING interaction network

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UBA2

SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (640 aa)

Predicted Functional Partners:

SAE1

0.997

SUMO1

0.929

UBE2I

0.901

ENSCAFP00000053122

0.901

SUMO2

0.893

ENSCAFP00000049214

0.893

CLSTN1

0.830

ENSCAFP00000066119

0.822

DUS4L

0.781

SENP6

0.768

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLSTN1	DUS4L	ENSCAFP00000063522	ENSCAFP00000005834	Calsyntenin 1.	tRNA-dihydrouridine synthase; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the dus family.	0.623
CLSTN1	UBA2	ENSCAFP00000063522	ENSCAFP00000010792	Calsyntenin 1.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.830
DUS4L	CLSTN1	ENSCAFP00000005834	ENSCAFP00000063522	tRNA-dihydrouridine synthase; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the dus family.	Calsyntenin 1.	0.623
DUS4L	UBA2	ENSCAFP00000005834	ENSCAFP00000010792	tRNA-dihydrouridine synthase; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the dus family.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.781
ENSCAFP00000049214	ENSCAFP00000053122	ENSCAFP00000049214	ENSCAFP00000053122	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.859
ENSCAFP00000049214	ENSCAFP00000066119	ENSCAFP00000049214	ENSCAFP00000066119	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.744
ENSCAFP00000049214	SAE1	ENSCAFP00000049214	ENSCAFP00000057844	Ubiquitin-like domain-containing protein.	SUMO1 activating enzyme subunit 1.	0.916
ENSCAFP00000049214	SENP6	ENSCAFP00000049214	ENSCAFP00000003969	Ubiquitin-like domain-containing protein.	SUMO specific peptidase 6.	0.687
ENSCAFP00000049214	SUMO2	ENSCAFP00000049214	ENSCAFP00000007040	Ubiquitin-like domain-containing protein.	Small ubiquitin-related modifier.	0.744
ENSCAFP00000049214	UBA2	ENSCAFP00000049214	ENSCAFP00000010792	Ubiquitin-like domain-containing protein.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.893
ENSCAFP00000049214	UBE2I	ENSCAFP00000049214	ENSCAFP00000037556	Ubiquitin-like domain-containing protein.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.859
ENSCAFP00000053122	ENSCAFP00000049214	ENSCAFP00000053122	ENSCAFP00000049214	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.859
ENSCAFP00000053122	ENSCAFP00000066119	ENSCAFP00000053122	ENSCAFP00000066119	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.756
ENSCAFP00000053122	SAE1	ENSCAFP00000053122	ENSCAFP00000057844	UBIQUITIN_CONJUGAT_2 domain-containing protein.	SUMO1 activating enzyme subunit 1.	0.915
ENSCAFP00000053122	SENP6	ENSCAFP00000053122	ENSCAFP00000003969	UBIQUITIN_CONJUGAT_2 domain-containing protein.	SUMO specific peptidase 6.	0.589
ENSCAFP00000053122	SUMO1	ENSCAFP00000053122	ENSCAFP00000052182	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Rad60-SLD domain-containing protein.	0.859
ENSCAFP00000053122	SUMO2	ENSCAFP00000053122	ENSCAFP00000007040	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Small ubiquitin-related modifier.	0.756
ENSCAFP00000053122	UBA2	ENSCAFP00000053122	ENSCAFP00000010792	UBIQUITIN_CONJUGAT_2 domain-containing protein.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.901
ENSCAFP00000066119	ENSCAFP00000049214	ENSCAFP00000066119	ENSCAFP00000049214	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.744
ENSCAFP00000066119	ENSCAFP00000053122	ENSCAFP00000066119	ENSCAFP00000053122	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.756

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