UBA2 protein (Canis lupus familiaris) - STRING interaction network

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UBA2

SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (640 aa)

Predicted Functional Partners:

SAE1

0.995

SUMO1

0.932

SUMO2

0.915

ENSCAFP00000049214

0.889

UBE2I

0.884

ENSCAFP00000053122

0.882

ENSCAFP00000066119

0.882

CLSTN1

0.818

KCTD2

0.794

DUS4L

0.782

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLSTN1	DUS4L	ENSCAFP00000063522	ENSCAFP00000005834	Calsyntenin 1.	tRNA-dihydrouridine synthase; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the dus family.	0.641
CLSTN1	UBA2	ENSCAFP00000063522	ENSCAFP00000010792	Calsyntenin 1.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.818
DUS4L	CLSTN1	ENSCAFP00000005834	ENSCAFP00000063522	tRNA-dihydrouridine synthase; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the dus family.	Calsyntenin 1.	0.641
DUS4L	UBA2	ENSCAFP00000005834	ENSCAFP00000010792	tRNA-dihydrouridine synthase; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the dus family.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.782
ENSCAFP00000049214	ENSCAFP00000053122	ENSCAFP00000049214	ENSCAFP00000053122	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.796
ENSCAFP00000049214	KCTD2	ENSCAFP00000049214	ENSCAFP00000007024	Ubiquitin-like domain-containing protein.	Potassium channel tetramerization domain containing 2.	0.674
ENSCAFP00000049214	SAE1	ENSCAFP00000049214	ENSCAFP00000057844	Ubiquitin-like domain-containing protein.	SUMO1 activating enzyme subunit 1.	0.936
ENSCAFP00000049214	UBA2	ENSCAFP00000049214	ENSCAFP00000010792	Ubiquitin-like domain-containing protein.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.889
ENSCAFP00000049214	UBE2I	ENSCAFP00000049214	ENSCAFP00000037556	Ubiquitin-like domain-containing protein.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.796
ENSCAFP00000053122	ENSCAFP00000049214	ENSCAFP00000053122	ENSCAFP00000049214	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.796
ENSCAFP00000053122	ENSCAFP00000066119	ENSCAFP00000053122	ENSCAFP00000066119	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Ubiquitin-like domain-containing protein.	0.754
ENSCAFP00000053122	SAE1	ENSCAFP00000053122	ENSCAFP00000057844	UBIQUITIN_CONJUGAT_2 domain-containing protein.	SUMO1 activating enzyme subunit 1.	0.810
ENSCAFP00000053122	SUMO1	ENSCAFP00000053122	ENSCAFP00000052182	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Rad60-SLD domain-containing protein.	0.796
ENSCAFP00000053122	SUMO2	ENSCAFP00000053122	ENSCAFP00000007040	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Small ubiquitin-related modifier.	0.754
ENSCAFP00000053122	UBA2	ENSCAFP00000053122	ENSCAFP00000010792	UBIQUITIN_CONJUGAT_2 domain-containing protein.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.882
ENSCAFP00000066119	ENSCAFP00000053122	ENSCAFP00000066119	ENSCAFP00000053122	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.754
ENSCAFP00000066119	KCTD2	ENSCAFP00000066119	ENSCAFP00000007024	Ubiquitin-like domain-containing protein.	Potassium channel tetramerization domain containing 2.	0.698
ENSCAFP00000066119	SAE1	ENSCAFP00000066119	ENSCAFP00000057844	Ubiquitin-like domain-containing protein.	SUMO1 activating enzyme subunit 1.	0.885
ENSCAFP00000066119	UBA2	ENSCAFP00000066119	ENSCAFP00000010792	Ubiquitin-like domain-containing protein.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.882
ENSCAFP00000066119	UBE2I	ENSCAFP00000066119	ENSCAFP00000037556	Ubiquitin-like domain-containing protein.	Ubiquitin conjugating enzyme E2 I; Belongs to the ubiquitin-conjugating enzyme family.	0.754

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