HECTD2 protein (Canis lupus familiaris) - STRING interaction network

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HECTD2

HECT domain E3 ubiquitin protein ligase 2. (777 aa)

Predicted Functional Partners:

NEURL1B

0.610

RPS27A

0.584

TP53

0.583

UBA52

0.577

TM2D1

0.527

NIPAL2

0.520

PCGF5

0.484

NOC3L

0.479

PLCE1

0.457

HERC1

0.455

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HECTD2	HERC1	ENSCAFP00000010795	ENSCAFP00000025065	HECT domain E3 ubiquitin protein ligase 2.	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1.	0.455
HECTD2	NEURL1B	ENSCAFP00000010795	ENSCAFP00000024740	HECT domain E3 ubiquitin protein ligase 2.	Neuralized E3 ubiquitin protein ligase 1B.	0.610
HECTD2	NIPAL2	ENSCAFP00000010795	ENSCAFP00000035150	HECT domain E3 ubiquitin protein ligase 2.	NIPA like domain containing 2.	0.520
HECTD2	NOC3L	ENSCAFP00000010795	ENSCAFP00000011885	HECT domain E3 ubiquitin protein ligase 2.	Nucleolar complex protein 3 homolog.	0.479
HECTD2	PCGF5	ENSCAFP00000010795	ENSCAFP00000010769	HECT domain E3 ubiquitin protein ligase 2.	Polycomb group ring finger 5.	0.484
HECTD2	PLCE1	ENSCAFP00000010795	ENSCAFP00000011841	HECT domain E3 ubiquitin protein ligase 2.	Phosphoinositide phospholipase C.	0.457
HECTD2	RPS27A	ENSCAFP00000010795	ENSCAFP00000031429	HECT domain E3 ubiquitin protein ligase 2.	Ubiquitin-like domain-containing protein.	0.584
HECTD2	TM2D1	ENSCAFP00000010795	ENSCAFP00000053082	HECT domain E3 ubiquitin protein ligase 2.	TM2 domain containing 1.	0.527
HECTD2	TP53	ENSCAFP00000010795	ENSCAFP00000064590	HECT domain E3 ubiquitin protein ligase 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.583
HECTD2	UBA52	ENSCAFP00000010795	ENSCAFP00000021714	HECT domain E3 ubiquitin protein ligase 2.	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...]	0.577
HERC1	HECTD2	ENSCAFP00000025065	ENSCAFP00000010795	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1.	HECT domain E3 ubiquitin protein ligase 2.	0.455
HERC1	NEURL1B	ENSCAFP00000025065	ENSCAFP00000024740	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1.	Neuralized E3 ubiquitin protein ligase 1B.	0.679
HERC1	RPS27A	ENSCAFP00000025065	ENSCAFP00000031429	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1.	Ubiquitin-like domain-containing protein.	0.508
HERC1	TP53	ENSCAFP00000025065	ENSCAFP00000064590	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.741
HERC1	UBA52	ENSCAFP00000025065	ENSCAFP00000021714	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1.	Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...]	0.504
NEURL1B	HECTD2	ENSCAFP00000024740	ENSCAFP00000010795	Neuralized E3 ubiquitin protein ligase 1B.	HECT domain E3 ubiquitin protein ligase 2.	0.610
NEURL1B	HERC1	ENSCAFP00000024740	ENSCAFP00000025065	Neuralized E3 ubiquitin protein ligase 1B.	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1.	0.679
NIPAL2	HECTD2	ENSCAFP00000035150	ENSCAFP00000010795	NIPA like domain containing 2.	HECT domain E3 ubiquitin protein ligase 2.	0.520
NIPAL2	TM2D1	ENSCAFP00000035150	ENSCAFP00000053082	NIPA like domain containing 2.	TM2 domain containing 1.	0.528
NOC3L	HECTD2	ENSCAFP00000011885	ENSCAFP00000010795	Nucleolar complex protein 3 homolog.	HECT domain E3 ubiquitin protein ligase 2.	0.479