STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
KRT84Keratin 84; Belongs to the intermediate filament family. (564 aa)    
Predicted Functional Partners:
DSG1
Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
   
 0.891
KRTAP24-1
Keratin associated protein 24-1.
      
 0.826
DSG2
Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity).
   
 0.826
KRT85
IF rod domain-containing protein; Belongs to the intermediate filament family.
  
 
0.752
KRT24
Keratin 24; Belongs to the intermediate filament family.
  
0.733
KRT31
IF rod domain-containing protein; Belongs to the intermediate filament family.
  
0.730
CAPN12
Calpain 12; Belongs to the peptidase C2 family.
   
 
 0.716
KRT36
Keratin 36; Belongs to the intermediate filament family.
  
 
0.712
KRT18
IF rod domain-containing protein; Belongs to the intermediate filament family.
  
0.700
HPS5
Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
      
 0.698
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.