Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AXIN1 | AXIN2 | ENSCAFP00000054479 | ENSCAFP00000016564 | Axin 1. | Axin 2. | 0.847 |
| AXIN1 | CTNNB1 | ENSCAFP00000054479 | ENSCAFP00000007783 | Axin 1. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | 0.997 |
| AXIN1 | RNF146 | ENSCAFP00000054479 | ENSCAFP00000001501 | Axin 1. | Ring finger protein 146. | 0.817 |
| AXIN1 | TNKS2 | ENSCAFP00000054479 | ENSCAFP00000010845 | Axin 1. | Poly [ADP-ribose] polymerase. | 0.887 |
| AXIN2 | AXIN1 | ENSCAFP00000016564 | ENSCAFP00000054479 | Axin 2. | Axin 1. | 0.847 |
| AXIN2 | CTNNB1 | ENSCAFP00000016564 | ENSCAFP00000007783 | Axin 2. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | 0.949 |
| AXIN2 | RNF146 | ENSCAFP00000016564 | ENSCAFP00000001501 | Axin 2. | Ring finger protein 146. | 0.780 |
| AXIN2 | TNKS2 | ENSCAFP00000016564 | ENSCAFP00000010845 | Axin 2. | Poly [ADP-ribose] polymerase. | 0.926 |
| CTNNB1 | AXIN1 | ENSCAFP00000007783 | ENSCAFP00000054479 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | Axin 1. | 0.997 |
| CTNNB1 | AXIN2 | ENSCAFP00000007783 | ENSCAFP00000016564 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | Axin 2. | 0.949 |
| CTNNB1 | MCL1 | ENSCAFP00000007783 | ENSCAFP00000017738 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity); Belongs to the Bcl-2 family. | 0.602 |
| CTNNB1 | PTEN | ENSCAFP00000007783 | ENSCAFP00000045099 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] | 0.803 |
| CTNNB1 | TNKS2 | ENSCAFP00000007783 | ENSCAFP00000010845 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | Poly [ADP-ribose] polymerase. | 0.687 |
| HIF1AN | TNKS2 | ENSCAFP00000014261 | ENSCAFP00000010845 | Hypoxia inducible factor 1 subunit alpha inhibitor. | Poly [ADP-ribose] polymerase. | 0.889 |
| MCL1 | CTNNB1 | ENSCAFP00000017738 | ENSCAFP00000007783 | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity); Belongs to the Bcl-2 family. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | 0.602 |
| MCL1 | PTEN | ENSCAFP00000017738 | ENSCAFP00000045099 | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity); Belongs to the Bcl-2 family. | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor [...] | 0.598 |
| MCL1 | TNKS2 | ENSCAFP00000017738 | ENSCAFP00000010845 | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis (By similarity); Belongs to the Bcl-2 family. | Poly [ADP-ribose] polymerase. | 0.847 |
| PARP2 | RNF146 | ENSCAFP00000059353 | ENSCAFP00000001501 | Poly [ADP-ribose] polymerase. | Ring finger protein 146. | 0.745 |
| PARP2 | TNKS2 | ENSCAFP00000059353 | ENSCAFP00000010845 | Poly [ADP-ribose] polymerase. | Poly [ADP-ribose] polymerase. | 0.770 |
| PARP3 | RNF146 | ENSCAFP00000014771 | ENSCAFP00000001501 | Poly [ADP-ribose] polymerase. | Ring finger protein 146. | 0.416 |
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