STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GJB6Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (428 aa)    
Predicted Functional Partners:
SLC26A4
Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
      
 0.707
KCNJ10
Potassium voltage-gated channel subfamily J member 10.
      
 0.682
LHFPL5
LHFPL tetraspan subfamily member 5.
   
  
 0.644
TGM7
Transglutaminase 7.
   
  
 0.635
TMPRSS3
Transmembrane serine protease 3; Belongs to the peptidase S1 family.
   
  
 0.625
OTOF
Otoferlin.
   
  
 0.624
SLC26A5
Prestin; Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
      
 0.567
CNST
Consortin, connexin sorting protein.
    
 
 0.556
ESPN
Espin.
      
 0.546
KCNQ4
Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family.
   
  
 0.535
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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