PAH protein (Canis lupus familiaris) - STRING interaction network

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Score

PAH

Phenylalanine hydroxylase. (581 aa)

Predicted Functional Partners:

SPR

0.994

QDPR

0.973

PCBD1

0.959

TAT

0.956

PCBD2

0.954

DDC

0.939

GOT1

0.917

GOT1L1

0.915

TYR

0.904

ALDH3A1

0.890

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH3A1	DDC	ENSCAFP00000054381	ENSCAFP00000005077	Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity). Preferentially oxidizes aromatic aldehyde substrates (By similarity). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).	Dopa decarboxylase.	0.496
ALDH3A1	PAH	ENSCAFP00000054381	ENSCAFP00000010860	Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity). Preferentially oxidizes aromatic aldehyde substrates (By similarity). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).	Phenylalanine hydroxylase.	0.890
ALDH3A1	TYR	ENSCAFP00000054381	ENSCAFP00000006504	Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity). Preferentially oxidizes aromatic aldehyde substrates (By similarity). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).	Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Belongs to the tyrosinase family.	0.473
DDC	ALDH3A1	ENSCAFP00000005077	ENSCAFP00000054381	Dopa decarboxylase.	Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (By similarity). Preferentially oxidizes aromatic aldehyde substrates (By similarity). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).	0.496
DDC	GOT1	ENSCAFP00000005077	ENSCAFP00000013922	Dopa decarboxylase.	Aspartate aminotransferase.	0.896
DDC	GOT1L1	ENSCAFP00000005077	ENSCAFP00000009252	Dopa decarboxylase.	Glutamic-oxaloacetic transaminase 1 like 1.	0.894
DDC	PAH	ENSCAFP00000005077	ENSCAFP00000010860	Dopa decarboxylase.	Phenylalanine hydroxylase.	0.939
DDC	QDPR	ENSCAFP00000005077	ENSCAFP00000059975	Dopa decarboxylase.	Quinoid dihydropteridine reductase.	0.430
DDC	TAT	ENSCAFP00000005077	ENSCAFP00000032798	Dopa decarboxylase.	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.	0.915
DDC	TYR	ENSCAFP00000005077	ENSCAFP00000006504	Dopa decarboxylase.	Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Belongs to the tyrosinase family.	0.914
GOT1	DDC	ENSCAFP00000013922	ENSCAFP00000005077	Aspartate aminotransferase.	Dopa decarboxylase.	0.896
GOT1	GOT1L1	ENSCAFP00000013922	ENSCAFP00000009252	Aspartate aminotransferase.	Glutamic-oxaloacetic transaminase 1 like 1.	0.901
GOT1	PAH	ENSCAFP00000013922	ENSCAFP00000010860	Aspartate aminotransferase.	Phenylalanine hydroxylase.	0.917
GOT1	TAT	ENSCAFP00000013922	ENSCAFP00000032798	Aspartate aminotransferase.	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.	0.939
GOT1	TYR	ENSCAFP00000013922	ENSCAFP00000006504	Aspartate aminotransferase.	Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Belongs to the tyrosinase family.	0.884
GOT1L1	DDC	ENSCAFP00000009252	ENSCAFP00000005077	Glutamic-oxaloacetic transaminase 1 like 1.	Dopa decarboxylase.	0.894
GOT1L1	GOT1	ENSCAFP00000009252	ENSCAFP00000013922	Glutamic-oxaloacetic transaminase 1 like 1.	Aspartate aminotransferase.	0.901
GOT1L1	PAH	ENSCAFP00000009252	ENSCAFP00000010860	Glutamic-oxaloacetic transaminase 1 like 1.	Phenylalanine hydroxylase.	0.915
GOT1L1	TAT	ENSCAFP00000009252	ENSCAFP00000032798	Glutamic-oxaloacetic transaminase 1 like 1.	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.	0.921
GOT1L1	TYR	ENSCAFP00000009252	ENSCAFP00000006504	Glutamic-oxaloacetic transaminase 1 like 1.	Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Belongs to the tyrosinase family.	0.884