STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)    
Predicted Functional Partners:
SGK2
Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.
    
 0.971
PDPK1
3-phosphoinositide dependent protein kinase 1.
    
 0.949
SGK1
Non-specific serine/threonine protein kinase.
    
 0.939
FOXO1
Forkhead box O1.
    
 0.923
FOXO4
Forkhead box O4.
    
 0.920
FOXO3
Forkhead box O3.
    
 0.911
FOXI3
Forkhead box protein I3; Possible transcriptional factor. May play a role in the development of the epithelium of hair and whisker placodes and that of teeth.
    
 0.738
LOC484191
Uncharacterized protein.
 
  
 0.726
PRKDC
DNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act [...]
    
 0.666
MTOR
Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.
    
 0.666
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: medium (52%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.