IGKC protein (Canis lupus familiaris) - STRING interaction network

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Score

IGKC

Immunoglobulin kappa constant. (113 aa)

Predicted Functional Partners:

CD3E

0.923

CD3D

0.922

CD3G

0.920

CD247

0.905

F1PJW6_CANLF

0.904

LOC484343

0.617

ENSCAFP00000055032

0.552

TRAT1

0.550

ALCAM

0.540

RD3L

0.487

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALCAM	CD247	ENSCAFP00000014280	ENSCAFP00000041707	CD166 antigen; Cell adhesion molecule that mediates both heterotypic cell- cell contacts via its interaction with CD6, as well as homotypic cell- cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube f [...]	Uncharacterized protein.	0.545
ALCAM	CD3D	ENSCAFP00000014280	ENSCAFP00000038117	CD166 antigen; Cell adhesion molecule that mediates both heterotypic cell- cell contacts via its interaction with CD6, as well as homotypic cell- cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube f [...]	CD3d molecule.	0.556
ALCAM	CD3E	ENSCAFP00000014280	ENSCAFP00000052947	CD166 antigen; Cell adhesion molecule that mediates both heterotypic cell- cell contacts via its interaction with CD6, as well as homotypic cell- cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube f [...]	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	0.551
ALCAM	CD3G	ENSCAFP00000014280	ENSCAFP00000018809	CD166 antigen; Cell adhesion molecule that mediates both heterotypic cell- cell contacts via its interaction with CD6, as well as homotypic cell- cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube f [...]	CD3g molecule.	0.558
ALCAM	F1PJW6_CANLF	ENSCAFP00000014280	ENSCAFP00000034553	CD166 antigen; Cell adhesion molecule that mediates both heterotypic cell- cell contacts via its interaction with CD6, as well as homotypic cell- cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube f [...]	Uncharacterized protein.	0.556
ALCAM	IGKC	ENSCAFP00000014280	ENSCAFP00000010929	CD166 antigen; Cell adhesion molecule that mediates both heterotypic cell- cell contacts via its interaction with CD6, as well as homotypic cell- cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube f [...]	Immunoglobulin kappa constant.	0.540
ALCAM	TRAT1	ENSCAFP00000014280	ENSCAFP00000042632	CD166 antigen; Cell adhesion molecule that mediates both heterotypic cell- cell contacts via its interaction with CD6, as well as homotypic cell- cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube f [...]	T cell receptor associated transmembrane adaptor 1.	0.900
CD247	ALCAM	ENSCAFP00000041707	ENSCAFP00000014280	Uncharacterized protein.	CD166 antigen; Cell adhesion molecule that mediates both heterotypic cell- cell contacts via its interaction with CD6, as well as homotypic cell- cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube f [...]	0.545
CD247	CD3D	ENSCAFP00000041707	ENSCAFP00000038117	Uncharacterized protein.	CD3d molecule.	0.999
CD247	CD3E	ENSCAFP00000041707	ENSCAFP00000052947	Uncharacterized protein.	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	0.999
CD247	CD3G	ENSCAFP00000041707	ENSCAFP00000018809	Uncharacterized protein.	CD3g molecule.	0.999
CD247	F1PJW6_CANLF	ENSCAFP00000041707	ENSCAFP00000034553	Uncharacterized protein.	Uncharacterized protein.	0.955
CD247	IGKC	ENSCAFP00000041707	ENSCAFP00000010929	Uncharacterized protein.	Immunoglobulin kappa constant.	0.905
CD247	TRAT1	ENSCAFP00000041707	ENSCAFP00000042632	Uncharacterized protein.	T cell receptor associated transmembrane adaptor 1.	0.768
CD3D	ALCAM	ENSCAFP00000038117	ENSCAFP00000014280	CD3d molecule.	CD166 antigen; Cell adhesion molecule that mediates both heterotypic cell- cell contacts via its interaction with CD6, as well as homotypic cell- cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube f [...]	0.556
CD3D	CD247	ENSCAFP00000038117	ENSCAFP00000041707	CD3d molecule.	Uncharacterized protein.	0.999
CD3D	CD3E	ENSCAFP00000038117	ENSCAFP00000052947	CD3d molecule.	T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...]	0.999
CD3D	CD3G	ENSCAFP00000038117	ENSCAFP00000018809	CD3d molecule.	CD3g molecule.	0.999
CD3D	F1PJW6_CANLF	ENSCAFP00000038117	ENSCAFP00000034553	CD3d molecule.	Uncharacterized protein.	0.970
CD3D	IGKC	ENSCAFP00000038117	ENSCAFP00000010929	CD3d molecule.	Immunoglobulin kappa constant.	0.922