PARP4 protein (Canis lupus familiaris) - STRING interaction network

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Score

PARP4

Poly [ADP-ribose] polymerase. (1688 aa)

Predicted Functional Partners:

MVP

0.980

PARP3

0.938

PARP2

0.865

PARP1

0.843

TEP1

0.842

CASP3

0.829

CASP7

0.829

CASP9

0.829

PARG

0.820

CTSG

0.813

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP3	CASP7	ENSCAFP00000011475	ENSCAFP00000016420	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Caspase 7; Belongs to the peptidase C14A family.	0.928
CASP3	CASP9	ENSCAFP00000011475	ENSCAFP00000063413	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Caspase 9; Belongs to the peptidase C14A family.	0.997
CASP3	CTSG	ENSCAFP00000011475	ENSCAFP00000043060	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Granzyme B; Belongs to the peptidase S1 family.	0.965
CASP3	PARP1	ENSCAFP00000011475	ENSCAFP00000023715	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.998
CASP3	PARP2	ENSCAFP00000011475	ENSCAFP00000059353	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Poly [ADP-ribose] polymerase.	0.922
CASP3	PARP3	ENSCAFP00000011475	ENSCAFP00000014771	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Poly [ADP-ribose] polymerase.	0.910
CASP3	PARP4	ENSCAFP00000011475	ENSCAFP00000010963	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Poly [ADP-ribose] polymerase.	0.829
CASP7	CASP3	ENSCAFP00000016420	ENSCAFP00000011475	Caspase 7; Belongs to the peptidase C14A family.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.928
CASP7	CASP9	ENSCAFP00000016420	ENSCAFP00000063413	Caspase 7; Belongs to the peptidase C14A family.	Caspase 9; Belongs to the peptidase C14A family.	0.974
CASP7	CTSG	ENSCAFP00000016420	ENSCAFP00000043060	Caspase 7; Belongs to the peptidase C14A family.	Granzyme B; Belongs to the peptidase S1 family.	0.900
CASP7	PARP1	ENSCAFP00000016420	ENSCAFP00000023715	Caspase 7; Belongs to the peptidase C14A family.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.988
CASP7	PARP2	ENSCAFP00000016420	ENSCAFP00000059353	Caspase 7; Belongs to the peptidase C14A family.	Poly [ADP-ribose] polymerase.	0.922
CASP7	PARP3	ENSCAFP00000016420	ENSCAFP00000014771	Caspase 7; Belongs to the peptidase C14A family.	Poly [ADP-ribose] polymerase.	0.910
CASP7	PARP4	ENSCAFP00000016420	ENSCAFP00000010963	Caspase 7; Belongs to the peptidase C14A family.	Poly [ADP-ribose] polymerase.	0.829
CASP9	CASP3	ENSCAFP00000063413	ENSCAFP00000011475	Caspase 9; Belongs to the peptidase C14A family.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.997
CASP9	CASP7	ENSCAFP00000063413	ENSCAFP00000016420	Caspase 9; Belongs to the peptidase C14A family.	Caspase 7; Belongs to the peptidase C14A family.	0.974
CASP9	PARP1	ENSCAFP00000063413	ENSCAFP00000023715	Caspase 9; Belongs to the peptidase C14A family.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.967
CASP9	PARP2	ENSCAFP00000063413	ENSCAFP00000059353	Caspase 9; Belongs to the peptidase C14A family.	Poly [ADP-ribose] polymerase.	0.930
CASP9	PARP3	ENSCAFP00000063413	ENSCAFP00000014771	Caspase 9; Belongs to the peptidase C14A family.	Poly [ADP-ribose] polymerase.	0.910
CASP9	PARP4	ENSCAFP00000063413	ENSCAFP00000010963	Caspase 9; Belongs to the peptidase C14A family.	Poly [ADP-ribose] polymerase.	0.829