PARP4 protein (Canis lupus familiaris) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

PARP4

Poly [ADP-ribose] polymerase. (1688 aa)

Predicted Functional Partners:

CASP3

0.911

CASP7

0.911

MVP

0.911

CASP9

0.911

PARG

0.765

ZMYM2

0.745

PARP15

0.719

PARP14

0.699

TNKS2

0.663

TNKS

0.653

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP3	CASP7	ENSCAFP00000011475	ENSCAFP00000016420	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Caspase 7; Belongs to the peptidase C14A family.	0.916
CASP3	CASP9	ENSCAFP00000011475	ENSCAFP00000063413	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Caspase 9; Belongs to the peptidase C14A family.	0.979
CASP3	PARP4	ENSCAFP00000011475	ENSCAFP00000010963	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	Poly [ADP-ribose] polymerase.	0.911
CASP7	CASP3	ENSCAFP00000016420	ENSCAFP00000011475	Caspase 7; Belongs to the peptidase C14A family.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.916
CASP7	CASP9	ENSCAFP00000016420	ENSCAFP00000063413	Caspase 7; Belongs to the peptidase C14A family.	Caspase 9; Belongs to the peptidase C14A family.	0.949
CASP7	PARP4	ENSCAFP00000016420	ENSCAFP00000010963	Caspase 7; Belongs to the peptidase C14A family.	Poly [ADP-ribose] polymerase.	0.911
CASP9	CASP3	ENSCAFP00000063413	ENSCAFP00000011475	Caspase 9; Belongs to the peptidase C14A family.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.979
CASP9	CASP7	ENSCAFP00000063413	ENSCAFP00000016420	Caspase 9; Belongs to the peptidase C14A family.	Caspase 7; Belongs to the peptidase C14A family.	0.949
CASP9	PARP4	ENSCAFP00000063413	ENSCAFP00000010963	Caspase 9; Belongs to the peptidase C14A family.	Poly [ADP-ribose] polymerase.	0.911
MVP	PARP4	ENSCAFP00000050198	ENSCAFP00000010963	Uncharacterized protein.	Poly [ADP-ribose] polymerase.	0.911
PARG	PARP15	ENSCAFP00000010103	ENSCAFP00000017588	Poly(ADP-ribose) glycohydrolase.	Poly [ADP-ribose] polymerase.	0.616
PARG	PARP4	ENSCAFP00000010103	ENSCAFP00000010963	Poly(ADP-ribose) glycohydrolase.	Poly [ADP-ribose] polymerase.	0.765
PARG	TNKS	ENSCAFP00000010103	ENSCAFP00000009960	Poly(ADP-ribose) glycohydrolase.	Poly [ADP-ribose] polymerase.	0.641
PARG	TNKS2	ENSCAFP00000010103	ENSCAFP00000010845	Poly(ADP-ribose) glycohydrolase.	Poly [ADP-ribose] polymerase.	0.501
PARP14	PARP4	ENSCAFP00000052649	ENSCAFP00000010963	Poly(ADP-ribose) polymerase family member 14.	Poly [ADP-ribose] polymerase.	0.699
PARP15	PARG	ENSCAFP00000017588	ENSCAFP00000010103	Poly [ADP-ribose] polymerase.	Poly(ADP-ribose) glycohydrolase.	0.616
PARP15	PARP4	ENSCAFP00000017588	ENSCAFP00000010963	Poly [ADP-ribose] polymerase.	Poly [ADP-ribose] polymerase.	0.719
PARP15	TNKS	ENSCAFP00000017588	ENSCAFP00000009960	Poly [ADP-ribose] polymerase.	Poly [ADP-ribose] polymerase.	0.428
PARP4	CASP3	ENSCAFP00000010963	ENSCAFP00000011475	Poly [ADP-ribose] polymerase.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family.	0.911
PARP4	CASP7	ENSCAFP00000010963	ENSCAFP00000016420	Poly [ADP-ribose] polymerase.	Caspase 7; Belongs to the peptidase C14A family.	0.911