node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCL5 | CD2 | ENSCAFP00000063573 | ENSCAFP00000014445 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | CD2 molecule. | 0.560 |
CCL5 | CD3D | ENSCAFP00000063573 | ENSCAFP00000038117 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | CD3d molecule. | 0.604 |
CCL5 | CD3E | ENSCAFP00000063573 | ENSCAFP00000052947 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] | 0.457 |
CCL5 | CD8A | ENSCAFP00000063573 | ENSCAFP00000063962 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | T-cell surface glycoprotein CD8 alpha chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Sr [...] | 0.825 |
CCL5 | RPA2 | ENSCAFP00000063573 | ENSCAFP00000061592 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | Replication protein A2. | 0.409 |
CD2 | CCL5 | ENSCAFP00000014445 | ENSCAFP00000063573 | CD2 molecule. | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. | 0.560 |
CD2 | CD247 | ENSCAFP00000014445 | ENSCAFP00000041707 | CD2 molecule. | Uncharacterized protein. | 0.849 |
CD2 | CD3D | ENSCAFP00000014445 | ENSCAFP00000038117 | CD2 molecule. | CD3d molecule. | 0.849 |
CD2 | CD3E | ENSCAFP00000014445 | ENSCAFP00000052947 | CD2 molecule. | T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] | 0.923 |
CD2 | CD3G | ENSCAFP00000014445 | ENSCAFP00000018809 | CD2 molecule. | CD3g molecule. | 0.748 |
CD2 | CD8A | ENSCAFP00000014445 | ENSCAFP00000063962 | CD2 molecule. | T-cell surface glycoprotein CD8 alpha chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Sr [...] | 0.820 |
CD2 | CD8B | ENSCAFP00000014445 | ENSCAFP00000032014 | CD2 molecule. | Ig-like domain-containing protein. | 0.470 |
CD247 | CD2 | ENSCAFP00000041707 | ENSCAFP00000014445 | Uncharacterized protein. | CD2 molecule. | 0.849 |
CD247 | CD3D | ENSCAFP00000041707 | ENSCAFP00000038117 | Uncharacterized protein. | CD3d molecule. | 0.997 |
CD247 | CD3E | ENSCAFP00000041707 | ENSCAFP00000052947 | Uncharacterized protein. | T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] | 0.993 |
CD247 | CD3G | ENSCAFP00000041707 | ENSCAFP00000018809 | Uncharacterized protein. | CD3g molecule. | 0.999 |
CD247 | CD8A | ENSCAFP00000041707 | ENSCAFP00000063962 | Uncharacterized protein. | T-cell surface glycoprotein CD8 alpha chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Sr [...] | 0.965 |
CD247 | CD8B | ENSCAFP00000041707 | ENSCAFP00000032014 | Uncharacterized protein. | Ig-like domain-containing protein. | 0.731 |
CD247 | DLA-79 | ENSCAFP00000041707 | ENSCAFP00000065183 | Uncharacterized protein. | Ig-like domain-containing protein; Belongs to the MHC class I family. | 0.651 |
CD247 | DLA88 | ENSCAFP00000041707 | ENSCAFP00000000716 | Uncharacterized protein. | DLA class I histocompatibility antigen, A9/A9 alpha chain; Involved in the presentation of foreign antigens to the immune system. | 0.651 |