STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHCYAdenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. (425 aa)    
Predicted Functional Partners:
ASIP
Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment).
   
  
 0.783
CBS
Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 0.781
CTH
Cystathionine gamma-lyase.
  
 0.763
ITCH
E3 ubiquitin-protein ligase.
   
 
 0.713
MAT2A
S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
  
 
 0.702
MTR
5-methyltetrahydrofolate-homocysteine methyltransferase.
  
 
 0.688
C15H1orf50
Chromosome 15 C1orf50 homolog.
   
   0.688
RALY
RRM domain-containing protein.
   
  
 0.683
MAT1A
S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.
  
 
 0.645
BHMT
Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism.
  
 
 0.617
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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