STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AHCYAdenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. (425 aa)    
Predicted Functional Partners:
GNMT
Glycine N-methyltransferase.
   
 
 0.920
MTR
5-methyltetrahydrofolate-homocysteine methyltransferase.
  
 
 0.903
AHCYL2
Adenosylhomocysteinase like 2; Belongs to the adenosylhomocysteinase family.
    
  0.895
AHCYL1
Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family.
    
  0.895
CBS
Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 0.885
CTH
Cystathionine gamma-lyase.
  
 0.858
BHMT
Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism.
  
 
 0.830
KYAT1
Kynurenine aminotransferase 1.
   
 0.825
ITCH
E3 ubiquitin-protein ligase.
   
 
 0.824
DNMT3A
DNA methyltransferase 3 alpha; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
     
 0.813
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.