STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADMProadrenomedullin N-20 terminal peptide; AM and PAMP are potent hypotensive and vasodilatator agents; Belongs to the adrenomedullin family. (249 aa)    
Predicted Functional Partners:
CALCRL
Calcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family.
   
 0.999
RAMP3
Receptor activity modifying protein 3.
    
 0.995
RAMP1
Receptor activity modifying protein 1.
   
 0.990
RAMP2
Uncharacterized protein.
    
 0.981
IAPP
Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism; Belongs to the calcitonin family.
     
 0.980
CALCR
Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.
    
 0.979
CRSP-4
Calcitonin receptor-stimulating peptide 2.
     
 0.937
CALCB
Calcitonin receptor-stimulating peptide 1; Stimulates cAMP production in porcine kidney cell line LLC- PK1 via the calcitonin receptor (CT) but not via the CT-like (CL) receptor.
     
 0.920
MRGPRX2
G_PROTEIN_RECEP_F1_2 domain-containing protein.
    
 
 0.793
ADM2
Adrenomedullin 2.
   
 
 0.768
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.