STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLEKHF1Pleckstrin homology and FYVE domain containing 1. (465 aa)    
Predicted Functional Partners:
TNFSF10
Tumor necrosis factor ligand superfamily member.
   
  
 0.575
GADD45B
Growth arrest and DNA damage inducible beta.
   
  
 0.570
BCL2A1
BCL2 related protein A1.
   
  
 0.562
SEC24A
SEC24 homolog A, COPII coat complex component.
    
 
 0.561
C4H1orf198
Chromosome 4 C1orf198 homolog.
   
  
 0.559
ATP10A
Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
   
  
 0.535
NEDD9
Neural precursor cell expressed, developmentally down-regulated 9.
    
 
 0.528
DHRS9
Dehydrogenase/reductase 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
  
 0.516
PRSS22
Serine protease 22; Belongs to the peptidase S1 family.
   
  
 0.516
HNMT
Histamine N-methyltransferase.
      
 0.515
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.