PREX2 protein (Canis lupus familiaris) - STRING interaction network

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Score

PREX2

Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1605 aa)

Predicted Functional Partners:

GNB5

0.839

GNB3

0.839

PIK3CD

0.799

PIK3CA

0.788

PIK3CB

0.786

RAC2

0.778

RAC3

0.778

RAC1

0.778

GNG12

0.770

GNG8

0.768

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GNB3	GNB5	ENSCAFP00000058821	ENSCAFP00000023022	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	G protein subunit beta 5.	0.839
GNB3	GNG12	ENSCAFP00000058821	ENSCAFP00000041436	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.990
GNB3	GNG8	ENSCAFP00000058821	ENSCAFP00000006355	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.994
GNB3	PIK3CA	ENSCAFP00000058821	ENSCAFP00000048355	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.914
GNB3	PIK3CB	ENSCAFP00000058821	ENSCAFP00000011245	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.827
GNB3	PIK3CD	ENSCAFP00000058821	ENSCAFP00000029210	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family.	0.893
GNB3	PREX2	ENSCAFP00000058821	ENSCAFP00000011335	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2.	0.839
GNB3	RAC1	ENSCAFP00000058821	ENSCAFP00000032062	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]	0.811
GNB3	RAC2	ENSCAFP00000058821	ENSCAFP00000002174	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Rac family small GTPase 2.	0.841
GNB3	RAC3	ENSCAFP00000058821	ENSCAFP00000008868	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Uncharacterized protein.	0.811
GNB5	GNB3	ENSCAFP00000023022	ENSCAFP00000058821	G protein subunit beta 5.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.839
GNB5	GNG12	ENSCAFP00000023022	ENSCAFP00000041436	G protein subunit beta 5.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.990
GNB5	GNG8	ENSCAFP00000023022	ENSCAFP00000006355	G protein subunit beta 5.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.945
GNB5	PIK3CA	ENSCAFP00000023022	ENSCAFP00000048355	G protein subunit beta 5.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.821
GNB5	PIK3CB	ENSCAFP00000023022	ENSCAFP00000011245	G protein subunit beta 5.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.821
GNB5	PIK3CD	ENSCAFP00000023022	ENSCAFP00000029210	G protein subunit beta 5.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family.	0.889
GNB5	PREX2	ENSCAFP00000023022	ENSCAFP00000011335	G protein subunit beta 5.	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2.	0.839
GNB5	RAC1	ENSCAFP00000023022	ENSCAFP00000032062	G protein subunit beta 5.	Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity [...]	0.816
GNB5	RAC2	ENSCAFP00000023022	ENSCAFP00000002174	G protein subunit beta 5.	Rac family small GTPase 2.	0.867
GNB5	RAC3	ENSCAFP00000023022	ENSCAFP00000008868	G protein subunit beta 5.	Uncharacterized protein.	0.816