STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DTX4Deltex E3 ubiquitin ligase 4. (1040 aa)    
Predicted Functional Partners:
NOTCH2
Notch receptor 2.
     
 0.878
NOTCH1
Notch receptor 1.
    
 0.834
NOTCH3
Notch receptor 3.
     
 0.822
NOTCH4
Notch receptor 4.
     
 0.814
ITCH
E3 ubiquitin-protein ligase.
     
 0.706
DTX3
Deltex E3 ubiquitin ligase 3.
    
 0.655
DTX3L
Deltex E3 ubiquitin ligase 3L.
    
 0.652
TBK1
TANK binding kinase 1.
    
 
 0.646
EYS
Uncharacterized protein.
     
 0.632
EYS-2
Uncharacterized protein.
     
 0.632
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.