STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
HPF1Histone PARylation factor 1. (345 aa)    
Predicted Functional Partners:
PARP2
Poly [ADP-ribose] polymerase.
   
 
 0.888
PARP1
Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.
    
 
 0.846
PARP3
Poly [ADP-ribose] polymerase.
    
 
 0.831
ZNF2
Zinc finger protein 2.
      
 0.812
ZNF3
Zinc finger protein 3.
      
 0.778
PARG
Poly(ADP-ribose) glycohydrolase.
   
  
 0.648
PARP12
Poly(ADP-ribose) polymerase family member 12.
    
 
 0.634
PARP4
Poly [ADP-ribose] polymerase.
    
 
 0.634
MACROD1
Mono-ADP ribosylhydrolase 1.
    
 
 0.626
GMPPB
GDP-mannose pyrophosphorylase B.
   
   0.579
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.