STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CHD1Chromodomain helicase DNA binding protein 1. (1711 aa)    
Predicted Functional Partners:
RTF1
RTF1 homolog, Paf1/RNA polymerase II complex component.
   
 
 0.906
SSRP1
FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]
    
 
 0.842
PAF1
PAF1 homolog, Paf1/RNA polymerase II complex component.
    
 
 0.829
INO80C
INO80 complex subunit C.
    
 
 0.784
CTR9
CTR9 homolog, Paf1/RNA polymerase II complex component.
   
 
 0.742
RANBP2
RAN binding protein 2.
   
 
 0.667
NIPBL
Nipped-B protein.
   
 
 0.666
CDC73
Cell division cycle 73.
   
 
 0.665
SPOP
Speckle type BTB/POZ protein.
   
 
 0.656
SETD2
SET domain containing 2, histone lysine methyltransferase.
   
 
 0.631
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.