node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CACNA2D1 | KCNE5 | ENSCAFP00000009528 | ENSCAFP00000026670 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | Potassium voltage-gated channel subfamily E regulatory subunit 5. | 0.505 |
CACNA2D1 | SCN10A | ENSCAFP00000009528 | ENSCAFP00000011447 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | Sodium channel protein type 10 subunit alpha; Tetrodotoxin-resistant channel that mediates the voltage- dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms (By similarity); Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily. | 0.635 |
CACNA2D1 | SCN1B | ENSCAFP00000009528 | ENSCAFP00000010590 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | 0.647 |
CACNA2D1 | SCN3B | ENSCAFP00000009528 | ENSCAFP00000057747 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | Sodium voltage-gated channel beta subunit 3. | 0.619 |
CACNA2D1 | TRPM4 | ENSCAFP00000009528 | ENSCAFP00000005603 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | Transient receptor potential cation channel subfamily M member 4. | 0.507 |
KCNE5 | CACNA2D1 | ENSCAFP00000026670 | ENSCAFP00000009528 | Potassium voltage-gated channel subfamily E regulatory subunit 5. | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | 0.505 |
KCNE5 | KCNN3 | ENSCAFP00000026670 | ENSCAFP00000025287 | Potassium voltage-gated channel subfamily E regulatory subunit 5. | Potassium calcium-activated channel subfamily N member 3. | 0.573 |
KCNE5 | SCN10A | ENSCAFP00000026670 | ENSCAFP00000011447 | Potassium voltage-gated channel subfamily E regulatory subunit 5. | Sodium channel protein type 10 subunit alpha; Tetrodotoxin-resistant channel that mediates the voltage- dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms (By similarity); Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily. | 0.604 |
KCNE5 | SCN1B | ENSCAFP00000026670 | ENSCAFP00000010590 | Potassium voltage-gated channel subfamily E regulatory subunit 5. | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | 0.684 |
KCNE5 | SCN2B | ENSCAFP00000026670 | ENSCAFP00000042471 | Potassium voltage-gated channel subfamily E regulatory subunit 5. | Sodium channel subunit beta-2; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity). | 0.658 |
KCNE5 | SCN3B | ENSCAFP00000026670 | ENSCAFP00000057747 | Potassium voltage-gated channel subfamily E regulatory subunit 5. | Sodium voltage-gated channel beta subunit 3. | 0.719 |
KCNE5 | SCN4B | ENSCAFP00000026670 | ENSCAFP00000018868 | Potassium voltage-gated channel subfamily E regulatory subunit 5. | Sodium voltage-gated channel beta subunit 4. | 0.504 |
KCNN3 | KCNE5 | ENSCAFP00000025287 | ENSCAFP00000026670 | Potassium calcium-activated channel subfamily N member 3. | Potassium voltage-gated channel subfamily E regulatory subunit 5. | 0.573 |
KCNN3 | SCN10A | ENSCAFP00000025287 | ENSCAFP00000011447 | Potassium calcium-activated channel subfamily N member 3. | Sodium channel protein type 10 subunit alpha; Tetrodotoxin-resistant channel that mediates the voltage- dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms (By similarity); Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily. | 0.592 |
KCNN3 | SCN2B | ENSCAFP00000025287 | ENSCAFP00000042471 | Potassium calcium-activated channel subfamily N member 3. | Sodium channel subunit beta-2; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity). | 0.442 |
SCN10A | CACNA2D1 | ENSCAFP00000011447 | ENSCAFP00000009528 | Sodium channel protein type 10 subunit alpha; Tetrodotoxin-resistant channel that mediates the voltage- dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms (By similarity); Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily. | Calcium voltage-gated channel auxiliary subunit alpha2delta 1. | 0.635 |
SCN10A | KCNE5 | ENSCAFP00000011447 | ENSCAFP00000026670 | Sodium channel protein type 10 subunit alpha; Tetrodotoxin-resistant channel that mediates the voltage- dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms (By similarity); Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily. | Potassium voltage-gated channel subfamily E regulatory subunit 5. | 0.604 |
SCN10A | KCNN3 | ENSCAFP00000011447 | ENSCAFP00000025287 | Sodium channel protein type 10 subunit alpha; Tetrodotoxin-resistant channel that mediates the voltage- dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms (By similarity); Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily. | Potassium calcium-activated channel subfamily N member 3. | 0.592 |
SCN10A | SCN1B | ENSCAFP00000011447 | ENSCAFP00000010590 | Sodium channel protein type 10 subunit alpha; Tetrodotoxin-resistant channel that mediates the voltage- dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms (By similarity); Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily. | Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. | 0.864 |
SCN10A | SCN2B | ENSCAFP00000011447 | ENSCAFP00000042471 | Sodium channel protein type 10 subunit alpha; Tetrodotoxin-resistant channel that mediates the voltage- dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms (By similarity); Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily. | Sodium channel subunit beta-2; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity). | 0.882 |