Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
GGCXGamma-glutamyl carboxylase. (781 aa)    
Predicted Functional Partners:
VKORC1
Vitamin K epoxide reductase complex subunit 1.
   
 
 0.975
NQO1
NAD(P)H quinone dehydrogenase 1.
     
 0.941
F2
Coagulation factor II, thrombin; Belongs to the peptidase S1 family.
    
 0.919
F7
Coagulation factor X.
    
 0.918
PROC
Vitamin K-dependent protein C heavy chain; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family.
    
 0.918
PRRG2
Proline rich and Gla domain 2.
    
 
 0.898
MGP
Matrix Gla protein; Associates with the organic matrix of bone and cartilage.
    
 
 0.897
VKORC1L1
VKc domain-containing protein.
     
 0.855
NQO2
N-ribosyldihydronicotinamide:quinone reductase 2.
     
 0.814
SRFBP1
Serum response factor binding protein 1.
      
 0.811
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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