STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDK7Cyclin dependent kinase 7. (346 aa)    
Predicted Functional Partners:
CCNH
Cyclin H; Belongs to the cyclin family.
   
 0.999
CDK2
Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.
   
 0.993
MNAT1
MNAT1 component of CDK activating kinase.
   
 0.979
CDK1
Cyclin dependent kinase 1; Belongs to the protein kinase superfamily.
   
 0.978
GTF2H1
General transcription factor IIH subunit 1.
   
 0.977
GTF2H3
General transcription factor IIH subunit 3.
   
 0.973
ERCC2
ERCC excision repair 2, TFIIH core complex helicase subunit.
    
 
 0.966
GTF2H4
General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.
    
 0.963
ERCC3
ERCC excision repair 3, TFIIH core complex helicase subunit.
    
 
 0.963
POLR2A
DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.963
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.