node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFDN | CDH1 | ENSCAFP00000057828 | ENSCAFP00000030112 | Afadin, adherens junction formation factor. | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | 0.513 |
AFDN | CDH5 | ENSCAFP00000057828 | ENSCAFP00000030279 | Afadin, adherens junction formation factor. | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. | 0.541 |
AFDN | CTNND1 | ENSCAFP00000057828 | ENSCAFP00000011503 | Afadin, adherens junction formation factor. | Catenin delta 1. | 0.943 |
AFDN | RHOA | ENSCAFP00000057828 | ENSCAFP00000030438 | Afadin, adherens junction formation factor. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.406 |
CDH1 | AFDN | ENSCAFP00000030112 | ENSCAFP00000057828 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | Afadin, adherens junction formation factor. | 0.513 |
CDH1 | CDH5 | ENSCAFP00000030112 | ENSCAFP00000030279 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. | 0.656 |
CDH1 | CTNND1 | ENSCAFP00000030112 | ENSCAFP00000011503 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | Catenin delta 1. | 0.973 |
CDH1 | EGFR | ENSCAFP00000030112 | ENSCAFP00000005164 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | Receptor protein-tyrosine kinase. | 0.853 |
CDH1 | ERBB2 | ENSCAFP00000030112 | ENSCAFP00000024079 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...] | 0.594 |
CDH1 | LOC489647 | ENSCAFP00000030112 | ENSCAFP00000030107 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | Uncharacterized protein. | 0.904 |
CDH1 | MET | ENSCAFP00000030112 | ENSCAFP00000041478 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] | 0.424 |
CDH1 | RHOA | ENSCAFP00000030112 | ENSCAFP00000030438 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essent [...] | 0.574 |
CDH5 | AFDN | ENSCAFP00000030279 | ENSCAFP00000057828 | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. | Afadin, adherens junction formation factor. | 0.541 |
CDH5 | CDH1 | ENSCAFP00000030279 | ENSCAFP00000030112 | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | 0.656 |
CDH5 | CTNND1 | ENSCAFP00000030279 | ENSCAFP00000011503 | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. | Catenin delta 1. | 0.965 |
CDH5 | LOC489647 | ENSCAFP00000030279 | ENSCAFP00000030107 | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. | Uncharacterized protein. | 0.451 |
CDH5 | PTPRJ | ENSCAFP00000030279 | ENSCAFP00000036908 | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. | Protein tyrosine phosphatase receptor type J. | 0.533 |
CTNND1 | AFDN | ENSCAFP00000011503 | ENSCAFP00000057828 | Catenin delta 1. | Afadin, adherens junction formation factor. | 0.943 |
CTNND1 | CDH1 | ENSCAFP00000011503 | ENSCAFP00000030112 | Catenin delta 1. | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. | 0.973 |
CTNND1 | CDH5 | ENSCAFP00000011503 | ENSCAFP00000030279 | Catenin delta 1. | Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. | 0.965 |