HTR1F protein (Canis lupus familiaris) - STRING interaction network

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Score

HTR1F

5-hydroxytryptamine receptor 1F. (450 aa)

Predicted Functional Partners:

HTR1A

0.915

NPY

0.913

SST

0.911

GHRL

0.908

OXT

0.904

HTR5A

0.843

GNB4

0.801

GNB1

0.801

GNB2

0.801

GNAI1

0.794

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GHRL	HTR1A	ENSCAFP00000007641	ENSCAFP00000037035	Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family.	5-hydroxytryptamine receptor 1A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second [...]	0.932
GHRL	HTR1F	ENSCAFP00000007641	ENSCAFP00000011506	Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family.	5-hydroxytryptamine receptor 1F.	0.908
GHRL	NPY	ENSCAFP00000007641	ENSCAFP00000004135	Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family.	Neuropeptide Y.	0.916
GHRL	OXT	ENSCAFP00000007641	ENSCAFP00000048730	Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family.	Oxytocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family.	0.655
GHRL	SST	ENSCAFP00000007641	ENSCAFP00000064277	Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation (By similarity); Belongs to the motilin family.	Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin.	0.885
GNAI1	GNB1	ENSCAFP00000024156	ENSCAFP00000028342	G protein subunit alpha i1.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.956
GNAI1	GNB2	ENSCAFP00000024156	ENSCAFP00000033929	G protein subunit alpha i1.	G protein subunit beta 2.	0.884
GNAI1	GNB4	ENSCAFP00000024156	ENSCAFP00000016683	G protein subunit alpha i1.	G protein subunit beta 4.	0.956
GNAI1	HTR1A	ENSCAFP00000024156	ENSCAFP00000037035	G protein subunit alpha i1.	5-hydroxytryptamine receptor 1A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second [...]	0.762
GNAI1	HTR1F	ENSCAFP00000024156	ENSCAFP00000011506	G protein subunit alpha i1.	5-hydroxytryptamine receptor 1F.	0.794
GNAI1	HTR5A	ENSCAFP00000024156	ENSCAFP00000007567	G protein subunit alpha i1.	5-hydroxytryptamine receptor 5A.	0.795
GNB1	GNAI1	ENSCAFP00000028342	ENSCAFP00000024156	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	G protein subunit alpha i1.	0.956
GNB1	GNB2	ENSCAFP00000028342	ENSCAFP00000033929	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	G protein subunit beta 2.	0.558
GNB1	GNB4	ENSCAFP00000028342	ENSCAFP00000016683	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	G protein subunit beta 4.	0.408
GNB1	HTR1A	ENSCAFP00000028342	ENSCAFP00000037035	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	5-hydroxytryptamine receptor 1A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second [...]	0.767
GNB1	HTR1F	ENSCAFP00000028342	ENSCAFP00000011506	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	5-hydroxytryptamine receptor 1F.	0.801
GNB1	HTR5A	ENSCAFP00000028342	ENSCAFP00000007567	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	5-hydroxytryptamine receptor 5A.	0.794
GNB2	GNAI1	ENSCAFP00000033929	ENSCAFP00000024156	G protein subunit beta 2.	G protein subunit alpha i1.	0.884
GNB2	GNB1	ENSCAFP00000033929	ENSCAFP00000028342	G protein subunit beta 2.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.558
GNB2	GNB4	ENSCAFP00000033929	ENSCAFP00000016683	G protein subunit beta 2.	G protein subunit beta 4.	0.549