STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MAT2AS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (413 aa)    
Predicted Functional Partners:
MAT2B
Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.
  
 0.988
MTR
5-methyltetrahydrofolate-homocysteine methyltransferase.
  
 
 0.978
AMD1
Adenosylmethionine decarboxylase 1.
   
 
 0.970
BHMT
Betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism.
  
 
 0.970
BHMT2
Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism.
  
 
 0.962
TAT
Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.
  
 0.955
DNMT1
DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
   
 
 0.927
DNMT3B
DNA methyltransferase 3 beta; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
   
 
 0.903
MTHFR
Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
  
 
 0.901
E2R735_CANLF
Amino_oxidase domain-containing protein.
     
  0.900
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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