STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
POU1F1Pituitary-specific positive transcription factor 1; Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'. (291 aa)    
Predicted Functional Partners:
PROP1
Homeobox protein prophet of Pit-1; Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes; Belongs to the paired homeobox family.
    
 
 0.921
PRL
Prolactin.
   
 
 0.920
TSHB
Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism.
   
 
 0.900
LHX4
LIM homeobox 4.
   
 
 0.840
LHX3
LIM homeobox 3.
   
 
 0.839
HESX1
HESX homeobox 1.
   
 
 0.805
GHRHR
Growth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family.
   
  
 0.784
GH1
Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family.
   
 
 0.680
PAX4
Paired box 4.
   
 
 0.658
FSHB
Follicle stimulating hormone beta subunit.
   
  
 0.651
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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