STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ERAP2Aminopeptidase. (952 aa)    
Predicted Functional Partners:
DNPEP
Aspartyl aminopeptidase; Belongs to the peptidase M18 family.
      
 0.712
ACE2
Angiotensin-converting enzyme.
   
  
 0.708
ACE
Angiotensin-converting enzyme.
   
  
 0.678
LOC100856208
Angiotensin-converting enzyme.
   
  
 0.673
REN
Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.
   
  
 0.640
XPNPEP2
X-prolyl aminopeptidase 2; Belongs to the peptidase M24B family.
  
 
 0.617
CTSB
Cathepsin B; Belongs to the peptidase C1 family.
   
  
 0.612
RRAGA
Ras related GTP binding A.
   
  
 0.611
DPP4
Dipeptidyl peptidase 4; Belongs to the peptidase S9B family.
   
 
 0.601
AGT
Angiotensinogen; Belongs to the serpin family.
   
 
 0.598
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.