STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1362 aa)    
Predicted Functional Partners:
FBXW11
F-box and WD repeat domain containing 11.
    
 
 0.935
BTRC
Beta-transducin repeat containing E3 ubiquitin protein ligase.
    
 
 0.856
VCPIP1
Valosin containing protein interacting protein 1.
   
 
 0.714
TRIP12
Thyroid hormone receptor interactor 12.
   
  
 0.711
ZRANB1
Zinc finger RANBP2-type containing 1.
   
 
 0.696
AP4M1
AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (By similarity). It is also involved in protein sorting to the basolateral membrane in epithelial cells and [...]
    
   0.667
PSMA4
Proteasome subunit alpha 4.
      
 0.628
PLAA
Phospholipase A2 activating protein.
   
  
 0.625
OTULIN
OTU deubiquitinase with linear linkage specificity.
      
 0.625
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 
 0.622
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.