| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CREBBP | CTBP2 | ENSCAFP00000036447 | ENSCAFP00000051395 | CREB binding protein. | C-terminal binding protein 2. | 0.677 |
| CREBBP | CTNNB1 | ENSCAFP00000036447 | ENSCAFP00000007783 | CREB binding protein. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | 0.995 |
| CREBBP | LEF1 | ENSCAFP00000036447 | ENSCAFP00000056485 | CREB binding protein. | Lymphoid enhancer binding factor 1. | 0.966 |
| CREBBP | NLK | ENSCAFP00000036447 | ENSCAFP00000027521 | CREB binding protein. | Serine/threonine-protein kinase NLK; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhi [...] | 0.676 |
| CREBBP | TCF7 | ENSCAFP00000036447 | ENSCAFP00000043629 | CREB binding protein. | Transcription factor 7. | 0.960 |
| CREBBP | TCF7L1 | ENSCAFP00000036447 | ENSCAFP00000011603 | CREB binding protein. | Transcription factor 7 like 1. | 0.963 |
| CREBBP | TCF7L2 | ENSCAFP00000036447 | ENSCAFP00000039879 | CREB binding protein. | Transcription factor 7 like 2. | 0.931 |
| CREBBP | TLE1 | ENSCAFP00000036447 | ENSCAFP00000002118 | CREB binding protein. | TLE family member 1, transcriptional corepressor. | 0.560 |
| CTBP2 | CREBBP | ENSCAFP00000051395 | ENSCAFP00000036447 | C-terminal binding protein 2. | CREB binding protein. | 0.677 |
| CTBP2 | CTNNB1 | ENSCAFP00000051395 | ENSCAFP00000007783 | C-terminal binding protein 2. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | 0.570 |
| CTBP2 | LEF1 | ENSCAFP00000051395 | ENSCAFP00000056485 | C-terminal binding protein 2. | Lymphoid enhancer binding factor 1. | 0.918 |
| CTBP2 | TCF7 | ENSCAFP00000051395 | ENSCAFP00000043629 | C-terminal binding protein 2. | Transcription factor 7. | 0.915 |
| CTBP2 | TCF7L1 | ENSCAFP00000051395 | ENSCAFP00000011603 | C-terminal binding protein 2. | Transcription factor 7 like 1. | 0.973 |
| CTBP2 | TCF7L2 | ENSCAFP00000051395 | ENSCAFP00000039879 | C-terminal binding protein 2. | Transcription factor 7 like 2. | 0.928 |
| CTBP2 | TLE1 | ENSCAFP00000051395 | ENSCAFP00000002118 | C-terminal binding protein 2. | TLE family member 1, transcriptional corepressor. | 0.440 |
| CTNNB1 | CREBBP | ENSCAFP00000007783 | ENSCAFP00000036447 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | CREB binding protein. | 0.995 |
| CTNNB1 | CTBP2 | ENSCAFP00000007783 | ENSCAFP00000051395 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | C-terminal binding protein 2. | 0.570 |
| CTNNB1 | LEF1 | ENSCAFP00000007783 | ENSCAFP00000056485 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | Lymphoid enhancer binding factor 1. | 0.999 |
| CTNNB1 | NLK | ENSCAFP00000007783 | ENSCAFP00000027521 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | Serine/threonine-protein kinase NLK; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhi [...] | 0.632 |
| CTNNB1 | RUVBL1 | ENSCAFP00000007783 | ENSCAFP00000006114 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. | 0.985 |
