CDKN2AIP protein (Canis lupus familiaris) - STRING interaction network

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CDKN2AIP

CDKN2A interacting protein. (578 aa)

Predicted Functional Partners:

XRN2

0.923

CDKN2A

0.787

HNRNPDL

0.777

TUSC3

0.614

PCM1

0.613

ANGPT4

0.604

ANGPTL6

0.600

MDM2

0.569

TRAPPC11

0.547

TMEM145

0.547

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANGPT4	CDKN2AIP	ENSCAFP00000010234	ENSCAFP00000011669	Angiopoietin 4.	CDKN2A interacting protein.	0.604
ANGPTL6	CDKN2AIP	ENSCAFP00000026447	ENSCAFP00000011669	Angiopoietin like 6.	CDKN2A interacting protein.	0.600
CDKN2A	CDKN2AIP	ENSCAFP00000002445	ENSCAFP00000011669	Cyclin dependent kinase inhibitor 2B.	CDKN2A interacting protein.	0.787
CDKN2A	MDM2	ENSCAFP00000002445	ENSCAFP00000065951	Cyclin dependent kinase inhibitor 2B.	E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...]	0.975
CDKN2AIP	ANGPT4	ENSCAFP00000011669	ENSCAFP00000010234	CDKN2A interacting protein.	Angiopoietin 4.	0.604
CDKN2AIP	ANGPTL6	ENSCAFP00000011669	ENSCAFP00000026447	CDKN2A interacting protein.	Angiopoietin like 6.	0.600
CDKN2AIP	CDKN2A	ENSCAFP00000011669	ENSCAFP00000002445	CDKN2A interacting protein.	Cyclin dependent kinase inhibitor 2B.	0.787
CDKN2AIP	HNRNPDL	ENSCAFP00000011669	ENSCAFP00000049251	CDKN2A interacting protein.	Heterogeneous nuclear ribonucleoprotein D like.	0.777
CDKN2AIP	MDM2	ENSCAFP00000011669	ENSCAFP00000065951	CDKN2A interacting protein.	E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...]	0.569
CDKN2AIP	PCM1	ENSCAFP00000011669	ENSCAFP00000050479	CDKN2A interacting protein.	Pericentriolar material 1.	0.613
CDKN2AIP	TMEM145	ENSCAFP00000011669	ENSCAFP00000055898	CDKN2A interacting protein.	Transmembrane protein 145.	0.547
CDKN2AIP	TRAPPC11	ENSCAFP00000011669	ENSCAFP00000011627	CDKN2A interacting protein.	Trafficking protein particle complex 11.	0.547
CDKN2AIP	TUSC3	ENSCAFP00000011669	ENSCAFP00000061918	CDKN2A interacting protein.	Tumor suppressor candidate 3.	0.614
CDKN2AIP	XRN2	ENSCAFP00000011669	ENSCAFP00000007767	CDKN2A interacting protein.	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.	0.923
HNRNPDL	CDKN2AIP	ENSCAFP00000049251	ENSCAFP00000011669	Heterogeneous nuclear ribonucleoprotein D like.	CDKN2A interacting protein.	0.777
MDM2	CDKN2A	ENSCAFP00000065951	ENSCAFP00000002445	E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...]	Cyclin dependent kinase inhibitor 2B.	0.975
MDM2	CDKN2AIP	ENSCAFP00000065951	ENSCAFP00000011669	E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...]	CDKN2A interacting protein.	0.569
PCM1	CDKN2AIP	ENSCAFP00000050479	ENSCAFP00000011669	Pericentriolar material 1.	CDKN2A interacting protein.	0.613
PCM1	TUSC3	ENSCAFP00000050479	ENSCAFP00000061918	Pericentriolar material 1.	Tumor suppressor candidate 3.	0.595
TMEM145	CDKN2AIP	ENSCAFP00000055898	ENSCAFP00000011669	Transmembrane protein 145.	CDKN2A interacting protein.	0.547