PRG3 protein (Canis lupus familiaris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PRG3

Proteoglycan 3, pro eosinophil major basic protein 2. (225 aa)

Predicted Functional Partners:

PAPPA

0.689

MYH1

0.568

ACTN3

0.562

PAPPA2

0.520

FTH1-2

0.454

PIK3R1

0.419

NFKB1

0.416

FOLR1

0.402

FTH1

0.400

TIMP2

0.400

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN3	MYH1	ENSCAFP00000018519	ENSCAFP00000025847	Actinin alpha 3.	Myosin-1; Muscle contraction.	0.718
ACTN3	PRG3	ENSCAFP00000018519	ENSCAFP00000011677	Actinin alpha 3.	Proteoglycan 3, pro eosinophil major basic protein 2.	0.562
FOLR1	FTH1	ENSCAFP00000047516	ENSCAFP00000023396	Folate_rec domain-containing protein.	Ferritin heavy chain, N-terminally processed; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).	0.400
FOLR1	FTH1-2	ENSCAFP00000047516	ENSCAFP00000033829	Folate_rec domain-containing protein.	Ferritin heavy chain.	0.411
FOLR1	NFKB1	ENSCAFP00000047516	ENSCAFP00000056706	Folate_rec domain-containing protein.	Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...]	0.423
FOLR1	PRG3	ENSCAFP00000047516	ENSCAFP00000011677	Folate_rec domain-containing protein.	Proteoglycan 3, pro eosinophil major basic protein 2.	0.402
FOLR1	TIMP2	ENSCAFP00000047516	ENSCAFP00000035219	Folate_rec domain-containing protein.	Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family.	0.406
FTH1	FOLR1	ENSCAFP00000023396	ENSCAFP00000047516	Ferritin heavy chain, N-terminally processed; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).	Folate_rec domain-containing protein.	0.400
FTH1	FTH1-2	ENSCAFP00000023396	ENSCAFP00000033829	Ferritin heavy chain, N-terminally processed; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).	Ferritin heavy chain.	0.404
FTH1	PRG3	ENSCAFP00000023396	ENSCAFP00000011677	Ferritin heavy chain, N-terminally processed; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).	Proteoglycan 3, pro eosinophil major basic protein 2.	0.400
FTH1	TIMP2	ENSCAFP00000023396	ENSCAFP00000035219	Ferritin heavy chain, N-terminally processed; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).	Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family.	0.400
FTH1-2	FOLR1	ENSCAFP00000033829	ENSCAFP00000047516	Ferritin heavy chain.	Folate_rec domain-containing protein.	0.411
FTH1-2	FTH1	ENSCAFP00000033829	ENSCAFP00000023396	Ferritin heavy chain.	Ferritin heavy chain, N-terminally processed; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).	0.404
FTH1-2	PRG3	ENSCAFP00000033829	ENSCAFP00000011677	Ferritin heavy chain.	Proteoglycan 3, pro eosinophil major basic protein 2.	0.454
FTH1-2	TIMP2	ENSCAFP00000033829	ENSCAFP00000035219	Ferritin heavy chain.	Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family.	0.400
MYH1	ACTN3	ENSCAFP00000025847	ENSCAFP00000018519	Myosin-1; Muscle contraction.	Actinin alpha 3.	0.718
MYH1	PRG3	ENSCAFP00000025847	ENSCAFP00000011677	Myosin-1; Muscle contraction.	Proteoglycan 3, pro eosinophil major basic protein 2.	0.568
NFKB1	FOLR1	ENSCAFP00000056706	ENSCAFP00000047516	Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...]	Folate_rec domain-containing protein.	0.423
NFKB1	PRG3	ENSCAFP00000056706	ENSCAFP00000011677	Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...]	Proteoglycan 3, pro eosinophil major basic protein 2.	0.416
NFKB1	TIMP2	ENSCAFP00000056706	ENSCAFP00000035219	Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...]	Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family.	0.561