PDE6C protein (Canis lupus familiaris) - STRING interaction network

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Score

PDE6C

Phosphodiesterase. (845 aa)

Predicted Functional Partners:

GNAT2

0.971

PDE6H

0.971

CNGB3

0.966

CNGA3

0.953

GUK1

0.917

ENPP1

0.909

PDE6G

0.899

ADCY8

0.897

GMPR2

0.895

ENTPD5

0.890

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY8	ENPP1	ENSCAFP00000001538	ENSCAFP00000000001	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Ectonucleotide pyrophosphatase/phosphodiesterase 1.	0.881
ADCY8	PDE6C	ENSCAFP00000001538	ENSCAFP00000011712	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase.	0.897
ADCY8	PDE6G	ENSCAFP00000001538	ENSCAFP00000008629	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G- protein-mediated phototransduction in vertebrate rods and cones.	0.881
ADCY8	PDE6H	ENSCAFP00000001538	ENSCAFP00000057342	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Phosphodiesterase 6H.	0.881
CNGA3	CNGB3	ENSCAFP00000066106	ENSCAFP00000013075	Cyclic nucleotide-gated channel alpha 3.	Cyclic nucleotide-gated cation channel beta-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses [...]	0.992
CNGA3	GNAT2	ENSCAFP00000066106	ENSCAFP00000029355	Cyclic nucleotide-gated channel alpha 3.	G protein subunit alpha transducin 2.	0.960
CNGA3	PDE6C	ENSCAFP00000066106	ENSCAFP00000011712	Cyclic nucleotide-gated channel alpha 3.	Phosphodiesterase.	0.953
CNGA3	PDE6H	ENSCAFP00000066106	ENSCAFP00000057342	Cyclic nucleotide-gated channel alpha 3.	Phosphodiesterase 6H.	0.899
CNGB3	CNGA3	ENSCAFP00000013075	ENSCAFP00000066106	Cyclic nucleotide-gated cation channel beta-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses [...]	Cyclic nucleotide-gated channel alpha 3.	0.992
CNGB3	GNAT2	ENSCAFP00000013075	ENSCAFP00000029355	Cyclic nucleotide-gated cation channel beta-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses [...]	G protein subunit alpha transducin 2.	0.966
CNGB3	PDE6C	ENSCAFP00000013075	ENSCAFP00000011712	Cyclic nucleotide-gated cation channel beta-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses [...]	Phosphodiesterase.	0.966
CNGB3	PDE6H	ENSCAFP00000013075	ENSCAFP00000057342	Cyclic nucleotide-gated cation channel beta-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses [...]	Phosphodiesterase 6H.	0.921
ENPP1	ADCY8	ENSCAFP00000000001	ENSCAFP00000001538	Ectonucleotide pyrophosphatase/phosphodiesterase 1.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.881
ENPP1	ENTPD5	ENSCAFP00000000001	ENSCAFP00000041007	Ectonucleotide pyrophosphatase/phosphodiesterase 1.	Ectonucleoside triphosphate diphosphohydrolase 5 (inactive); Belongs to the GDA1/CD39 NTPase family.	0.915
ENPP1	GMPR2	ENSCAFP00000000001	ENSCAFP00000017919	Ectonucleotide pyrophosphatase/phosphodiesterase 1.	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.	0.881
ENPP1	GUK1	ENSCAFP00000000001	ENSCAFP00000057276	Ectonucleotide pyrophosphatase/phosphodiesterase 1.	Guanylate kinase 1.	0.882
ENPP1	PDE6C	ENSCAFP00000000001	ENSCAFP00000011712	Ectonucleotide pyrophosphatase/phosphodiesterase 1.	Phosphodiesterase.	0.909
ENPP1	PDE6G	ENSCAFP00000000001	ENSCAFP00000008629	Ectonucleotide pyrophosphatase/phosphodiesterase 1.	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G- protein-mediated phototransduction in vertebrate rods and cones.	0.881
ENPP1	PDE6H	ENSCAFP00000000001	ENSCAFP00000057342	Ectonucleotide pyrophosphatase/phosphodiesterase 1.	Phosphodiesterase 6H.	0.883
ENTPD5	ENPP1	ENSCAFP00000041007	ENSCAFP00000000001	Ectonucleoside triphosphate diphosphohydrolase 5 (inactive); Belongs to the GDA1/CD39 NTPase family.	Ectonucleotide pyrophosphatase/phosphodiesterase 1.	0.915