STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
SSRP1FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (708 aa)    
Predicted Functional Partners:
SUPT16H
SPT16 homolog, facilitates chromatin remodeling subunit.
   
 0.999
TONSL
Tonsoku like, DNA repair protein.
   
 0.954
LEO1
LEO1 homolog, Paf1/RNA polymerase II complex component.
   
 0.946
MCM4
DNA helicase; Belongs to the MCM family.
   
 
 0.944
MCM2
DNA helicase; Belongs to the MCM family.
   
 
 0.943
CTR9
CTR9 homolog, Paf1/RNA polymerase II complex component.
   
 0.941
PAF1
PAF1 homolog, Paf1/RNA polymerase II complex component.
   
 0.916
SUPT6H
Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family.
   
 0.913
SUPT5H
Transcription elongation factor SPT5.
   
 0.908
MMS22L
MMS22 like, DNA repair protein.
    
 0.892
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.