STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MMP24Matrix metallopeptidase 24. (616 aa)    
Predicted Functional Partners:
HBEGF
Heparin binding EGF like growth factor.
   
 0.897
TIMP2
Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family.
   
 0.832
TIMP3
TIMP metallopeptidase inhibitor 3.
   
 0.721
MMP14
Matrix metallopeptidase 14.
  
 
0.672
CACNA2D2
Calcium voltage-gated channel auxiliary subunit alpha2delta 2.
      
 0.666
GNAI1
G protein subunit alpha i1.
     
  0.627
GNAI3
G protein subunit alpha i3.
     
  0.627
GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity).
     
  0.627
SERPINB1
Serpin family B member 1; Belongs to the serpin family.
    
 
 0.602
FURIN
Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family.
    
 0.588
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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