STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HESX1HESX homeobox 1. (186 aa)    
Predicted Functional Partners:
LHX3
LIM homeobox 3.
   
 
 0.851
POU1F1
Pituitary-specific positive transcription factor 1; Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.
   
 
 0.805
HELLS
Helicase, lymphoid specific.
    
 
 0.768
RGN
Regucalcin.
   
  
 0.698
ZPBP
Zona pellucida binding protein.
      
 0.676
PIK3R1
Phosphoinositide-3-kinase regulatory subunit 1.
      
 0.654
NAV2
Neuron navigator 2.
   
 
 0.627
IL18R1
Interleukin 18 receptor 1.
      
 0.606
SOX3
SRY-box 3.
      
 0.595
GTF3C2
General transcription factor IIIC subunit 2.
    
 0.549
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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