STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLCE1Phosphoinositide phospholipase C. (2309 aa)    
Predicted Functional Partners:
INPP5A
Inositol polyphosphate-5-phosphatase A; Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate.
     
 0.961
INPP5J
Inositol polyphosphate-5-phosphatase J.
     
 0.934
DGKG
Diacylglycerol kinase.
     
 0.924
PIP5K1B
Phosphatidylinositol-4-phosphate 5-kinase type 1 beta.
   
 0.922
ITPR1
Inositol 1,4,5-trisphosphate receptor type 1.
   
 
 0.921
DGKI
Diacylglycerol kinase.
    
 0.908
RAP1B
RAP1B, member of RAS oncogene family.
    
 0.903
RAP1A
RAP1A, member of RAS oncogene family.
    
 0.903
KRAS
KRAS proto-oncogene, GTPase.
    
 0.902
PI4KA
Phosphatidylinositol 4-kinase alpha; Belongs to the PI3/PI4-kinase family.
     
 0.896
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (24%) [HD]