STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SLF1SMC5-SMC6 complex localization factor 1. (956 aa)    
Predicted Functional Partners:
CDC45
Cell division cycle 45.
   
 
 0.980
PSMD12
Proteasome 26S subunit, non-ATPase 12.
    
 
 0.963
MCM5
Minichromosome maintenance complex component 5; Belongs to the MCM family.
   
 
 0.937
RAD18
RAD18 E3 ubiquitin protein ligase.
    
 
 0.924
MCM3
Minichromosome maintenance complex component 3; Belongs to the MCM family.
   
 
 0.912
TP53BP1
Tumor protein p53 binding protein 1.
    
 
 0.900
BARD1
BRCA1 associated RING domain 1.
   
 
0.855
ENSCAFP00000060790
Uncharacterized protein.
   
 
 0.855
ATR
ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.
    
 
 0.833
MDC1
Mediator of DNA damage checkpoint 1.
   
 
 0.832
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.