STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ELOCElongin C; Belongs to the SKP1 family. (112 aa)    
Predicted Functional Partners:
ELOB
Elongin B.
   
 0.999
CUL2
Cullin 2; Belongs to the cullin family.
   
 0.998
RBX1
Ring-box 1.
   
 0.997
RNF7
Ring finger protein 7.
   
 0.994
VHL
Von Hippel-Lindau disease tumor suppressor; Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (By similarity).
   
 0.991
CUL5
Cullin 5; Belongs to the cullin family.
   
 0.991
HIF1A
Uncharacterized protein.
   
 0.983
EPAS1
Endothelial PAS domain protein 1.
    
 0.919
KLHDC10
Kelch domain containing 10.
    
 0.911
SOCS5
Suppressor of cytokine signaling 5.
   
 0.907
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.