STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BTG3BTG anti-proliferation factor 3. (252 aa)    
Predicted Functional Partners:
PSPH
Phosphoserine phosphatase.
   
  
 0.683
GLG1
Golgi glycoprotein 1.
   
  
 0.660
PTGS1
Prostaglandin G/H synthase 1; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells (By similarity).
   
  
 0.641
CNOT7
CCR4-NOT transcription complex subunit 7.
   
 
 0.627
RBL2
RB transcriptional corepressor like 2.
   
  
 0.538
CNOT11
CCR4-NOT transcription complex subunit 11.
   
 
 0.527
PHKG2
Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily.
   
  
 0.527
SMURF2
E3 ubiquitin-protein ligase.
   
  
 0.496
GRAP2
GRB2 related adaptor protein 2.
      
 0.487
SHE
Src homology 2 domain containing E.
   
  
 0.485
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.