node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MYD88 | NFKB1 | ENSCAFP00000007386 | ENSCAFP00000056706 | MYD88 innate immune signal transduction adaptor. | Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] | 0.721 |
MYD88 | TICAM1 | ENSCAFP00000007386 | ENSCAFP00000033738 | MYD88 innate immune signal transduction adaptor. | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | 0.864 |
MYD88 | TICAM2 | ENSCAFP00000007386 | ENSCAFP00000000299 | MYD88 innate immune signal transduction adaptor. | TIR domain-containing protein. | 0.797 |
MYD88 | TIRAP | ENSCAFP00000007386 | ENSCAFP00000030551 | MYD88 innate immune signal transduction adaptor. | TIR domain containing adaptor protein. | 0.995 |
MYD88 | TLR1 | ENSCAFP00000007386 | ENSCAFP00000032660 | MYD88 innate immune signal transduction adaptor. | Toll like receptor 1; Belongs to the Toll-like receptor family. | 0.991 |
MYD88 | TLR2 | ENSCAFP00000007386 | ENSCAFP00000012269 | MYD88 innate immune signal transduction adaptor. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.993 |
MYD88 | TLR4 | ENSCAFP00000007386 | ENSCAFP00000031395 | MYD88 innate immune signal transduction adaptor. | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.987 |
MYD88 | TLR5 | ENSCAFP00000007386 | ENSCAFP00000016726 | MYD88 innate immune signal transduction adaptor. | TIR domain-containing protein; Belongs to the Toll-like receptor family. | 0.990 |
MYD88 | TLR6 | ENSCAFP00000007386 | ENSCAFP00000023836 | MYD88 innate immune signal transduction adaptor. | Toll like receptor 6; Belongs to the Toll-like receptor family. | 0.992 |
MYD88 | TOLLIP | ENSCAFP00000007386 | ENSCAFP00000062384 | MYD88 innate immune signal transduction adaptor. | Toll interacting protein. | 0.956 |
NFKB1 | MYD88 | ENSCAFP00000056706 | ENSCAFP00000007386 | Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] | MYD88 innate immune signal transduction adaptor. | 0.721 |
NFKB1 | TLR2 | ENSCAFP00000056706 | ENSCAFP00000012269 | Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.947 |
NFKB1 | TLR4 | ENSCAFP00000056706 | ENSCAFP00000031395 | Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] | Toll like receptor 4; Belongs to the Toll-like receptor family. | 0.938 |
NFKB1 | TLR5 | ENSCAFP00000056706 | ENSCAFP00000016726 | Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] | TIR domain-containing protein; Belongs to the Toll-like receptor family. | 0.931 |
NFKB1 | TOLLIP | ENSCAFP00000056706 | ENSCAFP00000062384 | Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] | Toll interacting protein. | 0.490 |
TICAM1 | MYD88 | ENSCAFP00000033738 | ENSCAFP00000007386 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | MYD88 innate immune signal transduction adaptor. | 0.864 |
TICAM1 | TICAM2 | ENSCAFP00000033738 | ENSCAFP00000000299 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | TIR domain-containing protein. | 0.958 |
TICAM1 | TIRAP | ENSCAFP00000033738 | ENSCAFP00000030551 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | TIR domain containing adaptor protein. | 0.754 |
TICAM1 | TLR1 | ENSCAFP00000033738 | ENSCAFP00000032660 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | Toll like receptor 1; Belongs to the Toll-like receptor family. | 0.405 |
TICAM1 | TLR2 | ENSCAFP00000033738 | ENSCAFP00000012269 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] | 0.966 |