STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PHF20PHD finger protein 20. (1013 aa)    
Predicted Functional Partners:
KANSL2
KAT8 regulatory NSL complex subunit 2.
    
 0.967
KANSL1
KAT8 regulatory NSL complex subunit 1.
    
 0.967
MCRS1
Microspherule protein 1.
   
 0.951
KANSL3
KAT8 regulatory NSL complex subunit 3.
    
 0.936
WDR5
WD repeat domain 5.
   
 0.931
KAT8
Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.
   
 0.929
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase.
   
 0.883
HCFC1
Host cell factor C1.
   
 0.839
SUDS3
SDS3 homolog, SIN3A corepressor complex component.
   
 
 0.757
MDM2
E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 [...]
   
 
  0.754
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.