STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
AQRRNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. (1418 aa)    
Predicted Functional Partners:
CRNKL1
Crooked neck pre-mRNA splicing factor 1.
   
 0.991
XAB2
XPA binding protein 2.
   
 0.991
PRPF19
Pre-mRNA processing factor 19.
    
 0.988
RBM22
RNA binding motif protein 22.
    
 0.987
ZNF830
Zinc finger protein 830.
    
 0.987
ISY1
Uncharacterized protein.
 
  
 0.973
PRPF8
Pre-mRNA processing factor 8.
   
 0.970
SNW1
SNW domain containing 1.
    
 0.968
DHX8
DEAH-box helicase 8.
   
 0.963
EIF4A3
Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family.
    
 
 0.961
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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