HTRA2 protein (Canis lupus familiaris) - STRING interaction network

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Score

HTRA2

Protease serine 25. (458 aa)

Predicted Functional Partners:

XIAP

0.996

PINK1

0.970

CYCS

0.965

BIRC2

0.963

BIRC6

0.960

BIRC3

0.945

TNFRSF1A

0.940

TNF

0.933

ARMC8

0.913

NDUFA13

0.868

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARMC8	HTRA2	ENSCAFP00000034746	ENSCAFP00000012325	Armadillo repeat containing 8.	Protease serine 25.	0.913
BIRC2	BIRC3	ENSCAFP00000022277	ENSCAFP00000050122	Baculoviral IAP repeat containing 2.	Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...]	0.866
BIRC2	BIRC6	ENSCAFP00000022277	ENSCAFP00000008679	Baculoviral IAP repeat containing 2.	Baculoviral IAP repeat containing 6.	0.484
BIRC2	HTRA2	ENSCAFP00000022277	ENSCAFP00000012325	Baculoviral IAP repeat containing 2.	Protease serine 25.	0.963
BIRC2	TNF	ENSCAFP00000022277	ENSCAFP00000000739	Baculoviral IAP repeat containing 2.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.897
BIRC2	TNFRSF1A	ENSCAFP00000022277	ENSCAFP00000062480	Baculoviral IAP repeat containing 2.	TNF receptor superfamily member 1A.	0.974
BIRC2	XIAP	ENSCAFP00000022277	ENSCAFP00000034255	Baculoviral IAP repeat containing 2.	Baculoviral IAP-repeat containing protein 4.	0.966
BIRC3	BIRC2	ENSCAFP00000050122	ENSCAFP00000022277	Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...]	Baculoviral IAP repeat containing 2.	0.866
BIRC3	BIRC6	ENSCAFP00000050122	ENSCAFP00000008679	Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...]	Baculoviral IAP repeat containing 6.	0.484
BIRC3	HTRA2	ENSCAFP00000050122	ENSCAFP00000012325	Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...]	Protease serine 25.	0.945
BIRC3	TNF	ENSCAFP00000050122	ENSCAFP00000000739	Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...]	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.901
BIRC3	TNFRSF1A	ENSCAFP00000050122	ENSCAFP00000062480	Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...]	TNF receptor superfamily member 1A.	0.981
BIRC3	XIAP	ENSCAFP00000050122	ENSCAFP00000034255	Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...]	Baculoviral IAP-repeat containing protein 4.	0.965
BIRC6	BIRC2	ENSCAFP00000008679	ENSCAFP00000022277	Baculoviral IAP repeat containing 6.	Baculoviral IAP repeat containing 2.	0.484
BIRC6	BIRC3	ENSCAFP00000008679	ENSCAFP00000050122	Baculoviral IAP repeat containing 6.	Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...]	0.484
BIRC6	HTRA2	ENSCAFP00000008679	ENSCAFP00000012325	Baculoviral IAP repeat containing 6.	Protease serine 25.	0.960
BIRC6	XIAP	ENSCAFP00000008679	ENSCAFP00000034255	Baculoviral IAP repeat containing 6.	Baculoviral IAP-repeat containing protein 4.	0.456
CYCS	HTRA2	ENSCAFP00000004225	ENSCAFP00000012325	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	Protease serine 25.	0.965
CYCS	NDUFA13	ENSCAFP00000004225	ENSCAFP00000021004	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	NADH:ubiquinone oxidoreductase subunit A13.	0.424
CYCS	PINK1	ENSCAFP00000004225	ENSCAFP00000057576	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	PTEN induced kinase 1.	0.703