HEY1 protein (Canis lupus familiaris) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Predicted Interactions

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Score

HEY1

Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...] (276 aa)

Predicted Functional Partners:

DLL4

0.824

NOTCH4

0.777

RBPJ

0.720

JAG1

0.699

NOTCH1

0.625

DLL1

0.612

EPHB4

0.604

NOTCH2

0.598

NOTCH3

0.595

JAG2

0.595

Your Current Organism:

Canis lupus familiaris

NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLL1	DLL4	ENSCAFP00000006075	ENSCAFP00000013852	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.915
DLL1	HEY1	ENSCAFP00000006075	ENSCAFP00000012336	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...]	0.612
DLL1	NOTCH1	ENSCAFP00000006075	ENSCAFP00000029073	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.996
DLL1	NOTCH2	ENSCAFP00000006075	ENSCAFP00000015629	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 2.	0.986
DLL1	NOTCH3	ENSCAFP00000006075	ENSCAFP00000023739	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.982
DLL1	NOTCH4	ENSCAFP00000006075	ENSCAFP00000001124	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 4.	0.820
DLL1	RBPJ	ENSCAFP00000006075	ENSCAFP00000064615	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region.	0.779
DLL4	DLL1	ENSCAFP00000013852	ENSCAFP00000006075	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.915
DLL4	EPHB4	ENSCAFP00000013852	ENSCAFP00000063136	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	EPH receptor B4.	0.677
DLL4	HEY1	ENSCAFP00000013852	ENSCAFP00000012336	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...]	0.824
DLL4	JAG2	ENSCAFP00000013852	ENSCAFP00000027180	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.440
DLL4	NOTCH1	ENSCAFP00000013852	ENSCAFP00000029073	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.998
DLL4	NOTCH2	ENSCAFP00000013852	ENSCAFP00000015629	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 2.	0.988
DLL4	NOTCH3	ENSCAFP00000013852	ENSCAFP00000023739	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.982
DLL4	NOTCH4	ENSCAFP00000013852	ENSCAFP00000001124	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 4.	0.944
DLL4	RBPJ	ENSCAFP00000013852	ENSCAFP00000064615	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region.	0.739
EPHB4	DLL4	ENSCAFP00000063136	ENSCAFP00000013852	EPH receptor B4.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.677
EPHB4	HEY1	ENSCAFP00000063136	ENSCAFP00000012336	EPH receptor B4.	Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...]	0.604
EPHB4	JAG1	ENSCAFP00000063136	ENSCAFP00000008417	EPH receptor B4.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.633
EPHB4	NOTCH1	ENSCAFP00000063136	ENSCAFP00000029073	EPH receptor B4.	Notch receptor 1.	0.531

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