STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
HEY1Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses tra [...] (276 aa)    
Predicted Functional Partners:
NOTCH1
Notch receptor 1.
    
 
 0.882
NOTCH4
Notch receptor 4.
   
 
 0.872
RBPJ
Recombination signal binding protein for immunoglobulin kappa J region.
    
 0.870
DLL4
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
   
 
 0.859
CRX
Cone-rod homeobox protein; Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors (By similarity); Belongs to the paired homeobox family.
    
 
 0.769
DLL1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
    
 
 0.769
INSR
Tyrosine-protein kinase receptor.
    
 
 0.760
JAG2
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
    
 
 0.749
CREB3L1
cAMP responsive element binding protein 3 like 1.
      
 0.748
JAG1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
    
 
 0.738
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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